INTENSIVE HOSPITAL MONITORING OF ADVERSE REACTIONS TO DRUGS
INTENSIVE HOSPITAL MONITORING OF ADVERSE REACTIONS TO DRUGS
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DOI：
10.1136/bmj.1.5643.531
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发表时间：
1969-01-01
影响因子：
105.7
通讯作者：
WADE, OL
中科院分区：
文献类型：
--
作者：
HURWITZ, N;WADE, OL
共有1，268名住院病人在住院期间由一名观察员进行监测。结果1,160例患者中，药物反应发生率为10.2%。大多数反应是由于药物的已知药理作用。虽然只有4例反应具有危及生命的严重性，但在观察到的129例反应中，80%的严重程度为中度。洋地黄制剂、支气管扩张药和氨苄青霉素的反应率最高。有人建议，与药物使用有关的不良反应的更大的调查将作出有益的贡献的问题。
A total of 1,268 patients admitted to hospital wards were kept under surveillance by one observer throughout their stay in hospital. All drugs given to them and the occurrence of adverse reactions were recorded.Drug reactions were found in 10·2% of the 1,160 patients who received drug therapy. Most reactions were due to known pharmacological actions of the drugs. Though only four reactions were of life-threatening seriousness, 80% of the 129 reactions observed were of moderate severity. Digitalis preparations, bronchodilator drugs, and ampicillin had the highest reaction rates. It is suggested that larger surveys of adverse reactions in relation to drug usage would make a useful contribution to the problem.