Nicotine serves as a feature-positive modulator of Pavlovian appetitive conditioning in rats
Nicotine serves as a feature-positive modulator of Pavlovian appetitive conditioning in rats
复制标题
DOI：
10.1097/01.fbp.0000132915.11693.8e
复制
发表时间：
2004-05-01
影响因子：
1.6
通讯作者：
Bevins, RA
中科院分区：
文献类型：
--
作者：
Palmatier, MI;Peterson, JL;Bevins, RA
本实验研究了尼古丁状态是否可以为大鼠的视觉线索和奖励结果之间的配对设置时机。尼古丁给药后，呈现条件刺激（CS;光照），随后短暂接触蔗糖溶液。当给予生理盐水时，出现相同的CS，但随后未出现任何后果。在实验1中，两组大鼠评估是否可以获得这种巴甫洛夫特征积极的歧视，通过不同的训练程序。预期的食物寻求条件反应（CR）开发过程中的尼古丁会议，但在两组盐水会议CS。在实验2中，烟碱乙酰胆碱和阿片受体（美加明和纳洛酮，分别）的中枢作用拮抗剂剂量依赖性地阻止尼古丁的控制CR，而外周作用的烟碱拮抗剂六甲双铵没有效果。增加或减少尼古丁给药和测试之间的间隔也会减弱CR。这些结果与尼古丁可通过其对中枢神经系统胆碱能受体的作用引起食欲巴甫洛夫关系的假设一致。
The present experiments examined whether a nicotine state could set the occasion for a pairing between visual cues and a rewarding outcome in rats. Following nicotine administration, presentation of a conditional stimulus (CS; light-on) was followed by brief access to a sucrose solution. When saline was administered, the same CS was presented but was not followed by any consequence. In Experiment 1, two groups assessed whether rats could acquire this Pavlovian feature-positive discrimination via different training procedures. An anticipatory food-seeking conditioned response (CR) developed during the CS on nicotine sessions but not on saline sessions in both groups. In Experiment 2, centrally acting antagonists of nicotinic acetylcholine and opiate receptors (mecamylamine and naloxone, respectively) dose-dependently blocked nicotine's control of the CR, whereas the peripherally acting nicotinic antagonist hexamethonium had no effect. Increasing or decreasing the interval between nicotine administration and testing also attenuated the CR. These results are consistent with the hypothesis that nicotine can occasion appetitive Pavlovian relations via its action at central nervous system cholinergic receptors.