New efficient nickel-catalyzed cross-coupling reaction between two Csp3 centers
New efficient nickel-catalyzed cross-coupling reaction between two Csp3 centers
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DOI：
10.1021/jo982317b
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发表时间：
1999-05-14
影响因子：
3.6
通讯作者：
Knochel, P
中科院分区：
文献类型：
--
作者：
Giovannini, R;Stüdemann, T;Knochel, P
卤代烷中存在远程不饱和基团（双键、羰基、氰基）有助于其在 Ni(acac)(2)（THF/NMP 混合物中为 7.5-10 mol%）存在下与各种二有机锌发生交叉偶联反应。这些结果用于开发功能化二有机锌和烷基碘之间的新通用交叉偶联反应，使用间三氟甲基苯乙烯或对三氟甲基苯乙烯作为反应促进剂，以 Ni(acac)(2) 作为催化剂（7.5-10 mol%；-35 ℃，5-10 h），从而产生多种多官能交叉偶联产物。
The presence of a remote unsaturation (double bond, carbonyl group, cyano group) in an alkyl halide facilitates its cross-coupling reaction with various diorganozincs in the presence of Ni(acac)(2) (7.5-10 mol % in THF/NMP mixtures). These results were used to develop a new general cross-coupling reaction between functionalized diorganozincs and alkyl iodides using m- or p-trifluoromethylstyrene as a reaction promotor and Ni(acac)(2) as a catalyst (7.5-10 mol %; -35 degrees C, 5-10 h) leading to a broad range of polyfunctional cross-coupling products'.