Interaction of childhood stress with hippocampus and prefrontal cortex volume reduction in major depression
Interaction of childhood stress with hippocampus and prefrontal cortex volume reduction in major depression
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DOI：
10.1016/j.jpsychires.2010.01.006
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发表时间：
2010-10-01
影响因子：
4.8
通讯作者：
Meisenzahl, Eva M.
中科院分区：
文献类型：
--
作者：
Frodl, Thomas;Reinhold, Elena;Meisenzahl, Eva M.
早期的情绪压力与后来抑郁的终生风险负担有关，而应激性生活事件会导致抑郁发作的发展。在这项研究中，我们调查了童年压力是否与重度抑郁症(MD)患者的脑结构改变有关。对43例MD患者和44例年龄、性别匹配的健康受试者进行高分辨率磁共振成像(MRI)检查。进行了海马区感兴趣区分析、基于全脑体素的形态测量(VBM)和儿童应激评估。与健康对照组相比，MD患者的海马区白质和前额叶灰质体积显著减小。特别是，与那些没有被忽视的患者相比，有情绪童年忽视的患者的左侧海马区白质更小。对于男性患者，这种影响出现在左侧和右侧的海马区。此外，童年时期的身体忽视影响了健康受试者的前额叶灰质体积。情绪忽视和脑结构异常都可以预测累积病程，情绪忽视与病程中的前额叶体积和海马白质之间存在显着的交互作用。童年忽视导致重度抑郁症患者的海马脑白质改变，左侧和男性明显。最有趣的是，童年压力和大脑结构体积独立预测累积病程。同时患有大脑结构变化和童年情感忽视的受试者，似乎有很高的风险发展成更严重的病程。(C)2010爱思唯尔有限公司。保留所有权利。
Early emotional stress is associated with a life-long burden of risk for later depression and stressful life events contribute to the development of depressive episodes. In this study we investigated whether childhood stress is associated with structural brain alterations in patients with major depression (MD). Forty-three patients with MD and 44 age as well as gender matched healthy control subjects were investigated using high-resolution magnetic resonance imaging (MRI). Region of interest analysis of the hippocampus, whole brain voxel-based morphometry (VBM) and assessment of childhood stress was carried out. Significantly smaller hippocampal white matter and prefrontal gray matter volume was observed in patients with MD compared to healthy controls. In particular left hippocampal white matter was smaller in patients, who had emotional childhood neglect, compared to those without neglect. For male patients this effect was seen in the left and right hippocampus. Moreover, physical neglect during childhood affected prefrontal gray matter volume in healthy subjects. Both emotional neglect and brain structural abnormalities predicted cumulative illness duration and there was a significant interaction between emotional neglect and prefrontal volumes as well as hippocampal white matter on the illness course. Childhood neglect resulted in hippocampal white matter changes in patients with major depression, pronounced at the left side and in males. Most interestingly, childhood stress and brain structure volumes independently predicted cumulative illness course. Subjects with both, structural brain changes and childhood emotional neglect seem to be at a very high risk to develop a more severe illness course. (C) 2010 Elsevier Ltd. All rights reserved.