The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeks
The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeks
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FTO 基因与人类脂肪量之间的关联在出生后两周内形成
DOI：
10.1210/jc.2007-2343
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发表时间：
2008-04-01
影响因子：
5.8
通讯作者：
Ibanez, Lourdes
中科院分区：
文献类型：
--
作者：
Lopez-Bermejo, Abel;Petry, Clive J.;Ibanez, Lourdes
目的：关于出生前后脂肪量的遗传决定因素知之甚少。我们假设FTO中常见的rs9939609单核苷酸多态性（SNP）与新生儿的脂肪量和代谢参数有关。设计：我们进行了一项以医院为基础的横断面研究。患者：234例足月健康新生儿（122名女孩，112名男孩）；胎龄（平均，范围）：39.0（37.0-42.0）周；出生体重，3.2 (1.9-4.2)kg]。方法：采用特异性免疫法测定脐带血胰岛素、IGF-I、igf结合蛋白-1、脂联素、visfatin。在约13 d（范围9-20 d）时，通过双能x线吸收仪评估体成分。rs9939609基因分型采用限制性内切片段长度多态性分析。结果：FTO中rs9939609 SNP与出生体重无相关性；但与血清内脂素（P < 0.001）、2周龄体重和体重指数（P < 0.05）以及总脂肪、躯干脂肪和腹部脂肪（P < 0.05 ~ P = 0.01）相关，因此AA纯合子的血浆内脂素浓度比t携带者高37%，总脂肪、躯干脂肪和腹部脂肪质量分别高17%、20%和17%。结论：我们的研究结果支持FTO基因中rs9939609 SNP在人类脂肪积累的早期阶段的作用，并揭示了该SNP与新生儿血清visfatin和腹部脂肪量之间的新关联。
Objective: Little is known about the genetic determinants of fat mass around birth. We hypothesized that the common rs9939609 single-nucleotide polymorphism (SNP) in FTO is associated with fat mass and metabolic parameters in neonates.Design: We conducted a cross-sectional, hospital-based study.Patients: Patients included 234 full-term, healthy newborns [122 girls and 112 boys; gestational age (mean, range), 39.0 (37.0-42.0) wk; birth weight, 3.2 (1.9-4.2) kg].Methods: Cord-blood insulin, IGF-I, IGF-binding protein-1, adiponectin, and visfatin were measured by specific immunoassays. Body composition was assessed by dual-energy x-ray absorptiometry at about 13 d (range, 9-20 d). Genotyping of rs9939609 was achieved by restriction fragment length polymorphism analysis.Results: The rs9939609 SNP in FTO was not associated with birth weight; however, it was associated with serum visfatin (P < 0.001), with weight and ponderal index at age 2 wk (P < 0.05), and with total, truncal, and abdominal fat (P < 0.05 to P = 0.01), so that AA homozygotes had 37% higher plasma visfatin concentration and 17, 20, and 17% higher total, truncal, and abdominal fat mass, respectively, than T-carrier neonates.Conclusion: Our findings support a role of the common rs9939609 SNP in FTO gene in the early stages of fat accretion in humans and disclose novel associations between this SNP and both serum visfatin and abdominal fat mass in neonates.