Siglecs and immune regulation.
Siglecs and immune regulation.
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DOI：
10.1146/annurev-immunol-020711-075018
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发表时间：
2012
影响因子：
29.7
通讯作者：
Mattoo H
中科院分区：
文献类型：
--
作者：
Pillai S;Netravali IA;Cariappa A;Mattoo H
唾液酸结合Ig样凝集素或Siglecs在其对含唾液酸的配体的特异性方面不同，并且主要由免疫系统的细胞表达。许多siglecs是在先天免疫细胞中表达的抑制性受体，其调节由DAMP和PAMP介导的炎症。该家族还包括参与粘附和吞噬作用的分子以及可以与含有DAP 12衔接子的ITAM缔合的受体。Siglecs通过与顺式配体（在相同细胞中表达）结合以及通过响应病原体衍生的唾液酸糖缀合物而有助于抑制免疫细胞。它们可以帮助维持B淋巴细胞的耐受性，调节常规和浆细胞样树突状细胞的活化，并直接和间接地促进T细胞功能的调节。Siglecs调节影响免疫系统中几乎每个细胞的免疫应答，并且与健康和疾病都相关。
Sialic acid binding Ig-like lectins or Siglecs vary in their specificity for sialic acid containing ligands and are mainly expressed by cells of the immune system. Many siglecs are inhibitory receptors expressed in innate immune cells that regulate inflammation mediated by DAMPs and PAMPs. This family also includes molecules involved in adhesion and phagocytosis and receptors that can associate with the ITAM containing DAP12 adaptor. Siglecs contribute to the inhibition of immune cells both by binding to cis-ligands (expressed in the same cells) as well as by responding to pathogen derived sialoglycoconjugates. They can help maintain tolerance in B lymphocytes, modulate the activation of conventional and plasmacytoid dendritic cells, and contribute to the regulation of T cell function both directly and indirectly. Siglecs modulate immune responses influencing almost every cell in the immune system, and are of relevance both in health and disease.
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DOI：
10.4049/jimmunol.1000454
发表时间：
2011-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Björck P;Leong HX;Engleman EG
通讯作者：
Engleman EG
影响因子：
4.8
作者：
Angata, T;Hingorani, R;Varki, A
通讯作者：
Varki, A
影响因子：
4.3
作者：
Angata, Takashi;Tabuchi, Yukako;Nakamura, Mitsuru
通讯作者：
Nakamura, Mitsuru
影响因子：
20.3
作者：
Blasius, A;Vermi, W;Colonna, M
通讯作者：
Colonna, M
影响因子：
4.4
作者：
Avril, T;Floyd, H;Crocker, PR
通讯作者：
Crocker, PR