Acute Stress Enhances Associative Learning via Dopamine Signaling in the Ventral Lateral Striatum
Acute Stress Enhances Associative Learning via Dopamine Signaling in the Ventral Lateral Striatum
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DOI：
10.1523/jneurosci.3003-19.2020
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发表时间：
2020-05-27
影响因子：
5.3
通讯作者：
Wanat, Matthew J.
中科院分区：
文献类型：
--
作者：
Stelly, Claire E.;Tritley, Sean C.;Wanat, Matthew J.
急性应激瞬间提高警觉性，增强对环境中显著刺激的检测能力。这种增加的感知敏感度被认为促进了奖励结果与相关线索的联系。中脑边缘多巴胺系统对于学习线索-奖赏关联至关重要。暴露在压力之下，腹侧纹状体中的多巴胺水平会升高。综上所述，这表明中脑边缘多巴胺系统可能在急性应激对线索-奖赏学习的影响中起中介作用。为了解决这种可能性，我们研究了一次单一的压力经历如何影响在食欲巴甫洛夫条件反射任务中的学习。雄性大鼠在第一次条件训练之前经历了一段时间的束缚。这种急性应激治疗在随后的治疗中增强了条件性反应。伏安法记录的中脑边缘多巴胺水平表明，急性应激选择性地增加腹侧纹状体(VLS)奖赏诱发的多巴胺释放，但不增加腹侧内侧纹状体的多巴胺释放。拮抗VLS中的多巴胺受体可阻断应激诱导的条件性反应的增强。总而言之，这些发现表明，压力参与了VLS中的多巴胺信号传递，从而促进了食欲学习。
Acute stress transiently increases vigilance, enhancing the detection of salient stimuli in one's environment. This increased perceptual sensitivity is thought to promote the association of rewarding outcomes with relevant cues. The mesolimbic dopamine system is critical for learning cue-reward associations. Dopamine levels in the ventral striatum are elevated following exposure to stress. Together, this suggests that the mesolimbic dopamine system could mediate the influence of acute stress on cue-reward learning. To address this possibility, we examined how a single stressful experience influenced learning in an appetitive pavlovian conditioning task. Male rats underwent an episode of restraint prior to the first conditioning session. This acute stress treatment augmented conditioned responding in subsequent sessions. Voltammetry recordings of mesolimbic dopamine levels demonstrated that acute stress selectively increased reward-evoked dopamine release in the ventral lateral striatum (VLS), but not in the ventral medial striatum. Antagonizing dopamine receptors in the VLS blocked the stress-induced enhancement of conditioned responding. Collectively, these findings illustrate that stress engages dopamine signaling in the VLS to facilitate appetitive learning.