Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer.
Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer.
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DOI：
10.3389/fonc.2012.00026
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发表时间：
2012
影响因子：
4.7
通讯作者：
Yan Q
中科院分区：
文献类型：
--
作者：
Cao J;Yan Q
组蛋白转录后修饰在所有DNA相关过程的调控中起着重要作用。其中，组蛋白泛素化的发现已有三十多年的历史。然而，它的功能仍然不如其他组蛋白修饰，如甲基化和乙酰化。本文就组蛋白泛素化和去泛素化的研究进展作一综述。特别是，我们将集中在它们是如何调节组蛋白泛素连接酶和去泛素化酶。然后，我们将讨论组蛋白泛素化在转录和DNA损伤反应中的作用，以及组蛋白泛素化和其他组蛋白修饰之间的串扰。最后，我们将回顾组蛋白泛素化在干细胞生物学和癌症中的重要作用。
Histone post-transcriptional modifications play essential roles in regulation of all DNA related processes. Among them, histone ubiquitination has been discovered for more than three decades. However, its functions are still less well understood than other histone modifications such as methylation and acetylation. In this review, we will summarize our current understanding of histone ubiquitination and deubiquitination. In particular, we will focus on how they are regulated by histone ubiquitin ligases and deubiquitinating enzymes. We will then discuss the roles of histone ubiquitination in transcription and DNA damage response and the crosstalk between histone ubiquitination and other histone modifications. Finally, we will review the important roles of histone ubiquitination in stem cell biology and cancer.