The role of the blood-brain barrier in movement disorders.
The role of the blood-brain barrier in movement disorders.
复制标题
血脑屏障在运动障碍中的作用。
DOI：
10.1097/00002826-199004000-00003
复制
发表时间：
1990
影响因子：
1
通讯作者：
Groothuis,DR
中科院分区：
文献类型：
--
作者：
Paleologos,NA;Groothuis,DR
The movement disorders represent a heterogeneous collection of diseases that are principally classified according to clinical characteristics since a coherent pathophysiological classification is still not possible. As such, they represent a potpourri of diseases when considered from the point of view of etiology, brain location, or pathology. Similarly, present neurochemical classifications of the movement disorders reflect loosely organized schemes, still in the process of conceptual evolution (1). In discussing the role of the blood–brain barrier (BBB) in movement disorders, we have tried to accommodate both the wide range of diseases encompassed by the term “movement disorders” and the changing concepts related to the classification and therapy of these diseases. We present this review first from the point of view of general principals with regard to BBB function, and then in terms of specific clinical diseases. It must be emphasized that there is no known movement disorder that is the result of a disease of theBBB itself, nor are there known abnormalities of the BBB in movement disorders. However, since the treatment of most movement disorders involves exogenously administered medications, the BBB can play a major role in determining the amount of medication that ultimately reaches the desired neuronal or synaptic substrate. Normal brain function depends upon adequate control of the levels of neurotransmitters and their precursors within the brain parenchyma; the BBB is the gatekeeper that regulates access of these compounds to the brain. The phrase blood–brain barrier (BBB) is used to describe the system of blood vessels in the brain, particularly capillaries, that serves as the interface between the rich and constantly changing mixture of nutrients and chemicals within the blood and the rather rigidly regulated composition of the extracellular fluid (ECF) in the brain. The structure and function of the BBB are closely related. There are several excellent general reviews of the structure and function of the BBB (2–5);
