BNT162b2 vaccine uptake and effectiveness in UK healthcare workers - a single centre cohort study.
BNT162b2 vaccine uptake and effectiveness in UK healthcare workers - a single centre cohort study.
复制标题
DOI：
10.1038/s41467-021-23927-x
复制
发表时间：
2021-06-17
影响因子：
16.6
通讯作者：
Warren S
中科院分区：
文献类型：
--
作者：
Azamgarhi T;Hodgkinson M;Shah A;Skinner JA;Hauptmannova I;Briggs TWR;Warren S
在这项单中心队列研究中，我们评估了在社区COVID-19高流行时期英国卫生保健工作者（HCWs）中BNT162B2疫苗的摄取和有效性。HCWs的早期接受率为62.3%(1409/2260)，但不同年龄组、种族血统和工作角色的接受率存在显著差异。在疫苗犹豫工作组实施具体措施后，接种率提高到72.9%。在接种疫苗后的42天内，共发现49例新发COVID-19病例，其中7例（14.3%）发生在接种疫苗超过10天的卫生保健工作者中。部分接种疫苗组和未接种疫苗组的Kaplan-Meier曲线直到第14天是一致的，直到第42天继续偏离。Cox回归分析显示，部分接种疫苗的医护人员感染COVID-19的风险降低70.0% （95%CI 6.0-91.0; p=0.04）。在这里，我们报告了卫生保健工作者的早期疫苗接种率通常很高，尽管某些群体的接种率较低。提高疫苗的吸收率是可能的，应将工作重点放在这方面，但是需要大量的资源。BNT162B2疫苗在一线临床环境中从接种疫苗后14天起有效，并且在不接种第二剂的情况下，在接种第一剂后的21天内继续具有保护作用。几种COVID-19疫苗已获得紧急批准。在这里，作者在一项单中心队列研究中描述了在社区COVID-19高流行时期，英国医护人员对BNT162B2疫苗的摄取和有效性。
In this single centre cohort study we assessed BNT162B2 vaccine uptake and effectiveness among UK healthcare workers (HCWs) during a time of high community COVID-19 prevalence. Early uptake among HCWs was 62.3% (1409/2260), however there were significant differences in uptake between age groups, ethnic origins, and job roles. Uptake increased to 72.9% after a vaccine hesitancy working group implemented specific measures. In the 42 days after vaccination, 49 new cases of COVID-19 were identified, of which 7 (14.3%) occurred in HCWs who were beyond 10 days of vaccination. Kaplan–Meier curves for partially vaccinated and unvaccinated groups were congruent until day 14 and continued to diverge up to 42 days. Cox regression analysis showed a 70.0% (95%CI 6.0–91.0; p=0.04) risk reduction for COVID-19 infection in partially vaccinated HCWs. Here we report early vaccination rates among HCWs are generally high although uptake is lower in certain groups. It is possible to improve vaccine uptake and efforts should focus on this, however, significant resource is required. The BNT162B2 vaccine is effective from 14 days post-vaccination in a frontline clinical setting and protection continues beyond 21 days post 1st dose without a 2nd dose, being given. Several vaccines for COVID-19 have received emergency approval. Here, the authors describe BNT162B2 vaccine uptake and effectiveness among UK healthcare workers in a single centre cohort study during a time of high community COVID-19 prevalence.
BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
英格兰医疗工人的COVID-19疫苗覆盖范围以及BNT162B2 mRNA疫苗对感染的有效性（Siren）：一项前瞻性，多中心，队列研究。
DOI：
10.1016/s0140-6736(21)00790-x
发表时间：
2021-05-08
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hall VJ;Foulkes S;Saei A;Andrews N;Oguti B;Charlett A;Wellington E;Stowe J;Gillson N;Atti A;Islam J;Karagiannis I;Munro K;Khawam J;Chand MA;Brown CS;Ramsay M;Lopez-Bernal J;Hopkins S;SIREN Study Group
通讯作者：
SIREN Study Group