Dlx genes, p63, and ectodermal dysplasias
Dlx genes, p63, and ectodermal dysplasias
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DOI：
10.1002/bdrc.20047
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发表时间：
2005-09-01
影响因子：
2.1
通讯作者：
Radoja, Nadezda
中科院分区：
文献类型：
--
作者：
Morasso, Maria I.;Radoja, Nadezda
脊椎动物的许多形态发生和器官发生都是由上皮/间充质相互作用引起的。这些过程涉及增厚的上皮层和下层间充质细胞之间一系列顺序和相互作用。从体外实验和小鼠基因敲除实验中，我们了解到调控上皮/间充质相互作用初始阶段的早期信号分子。在这篇综述中，我们讨论了这些初始信号的效应，特别是转录因子的p63和Dlx家族，它们在胚胎模式和不同发育过程的调节中起着核心作用，并对这些基因中与外胚层发育不良（EDs）相关的一些突变进行了综述。
Many events in vertebrate morphogenesis and organogenesis develop from epithelial/mesenchymal interactions. These processes involve a series of sequential and reciprocal interactions between the thickened epithelial sheets and underlying mesenchymal cells. Much has been learned from in vitro assays and knockout experiments in mice on the early signaling molecules that regulate the initial stages of the epithelial/mesenchymal interactions. In this review, we discuss effectors of these initial signals, specifically the p63 and Dlx families of transcription factors, that play central roles in embryonic patterning and regulation of different developmental processes, and provide a review of some of the mutations in these genes that have been associated with ectodermal dysplasias (EDs).