ANTIBODIES MEDIATING CELLULAR CYTOTOXICITY AND NEUTRALIZATION CORRELATE WITH A BETTER CLINICAL STAGE IN CHILDREN BORN TO HUMAN IMMUNODEFICIENCY VIRUS-INFECTED MOTHERS
ANTIBODIES MEDIATING CELLULAR CYTOTOXICITY AND NEUTRALIZATION CORRELATE WITH A BETTER CLINICAL STAGE IN CHILDREN BORN TO HUMAN IMMUNODEFICIENCY VIRUS-INFECTED MOTHERS
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DOI：
10.1093/infdis/161.2.198
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发表时间：
1990-02-01
影响因子：
6.4
通讯作者：
JONDAL, M
中科院分区：
文献类型：
--
作者：
LJUNGGREN, K;MOSCHESE, V;JONDAL, M
在人类免疫缺陷病毒（HIV）感染的母亲所生的儿童中，决定疾病结局和进展的因素尚不清楚。此外，早期诊断受到母体转移抗体的阻碍。根据15个月时的HIV血清反应性或无反应性，将0-24个月的儿童回顾性地分为两组，并分析介导细胞毒性（ADCC）和病毒中和的抗体的存在。两组间这些功能性抗体的存在无差异。根据血清采集时的临床状态，将持续血清阳性组进一步分为非AIDS组和AIDS组。非AIDS组ADCC抗体阳性率（70%）明显高于AIDS组（30%）。在非艾滋病儿童中，63%有中和抗体;没有艾滋病儿童有这些抗体。艾滋病毒特异性ADCC和中和抗体似乎并不能预防艾滋病毒从母亲到孩子的传播，但与儿童艾滋病毒感染的更好临床阶段显着相关。
In children born to human immunodeficiency virus (HIV)-infected mothers, factors that determine disease outcome and progression are unclear. Also, early diagnosis is hampered by maternally transferred antibodies. Children aged 0-24 months were retrospectively divided into two groups based on HIV seroreactivity or nonreactivity at age 15 months and analyzed for the presence of antibodies that mediate cellular cytotoxicity (ADCC) and virus neutralization. No difference was seen in the presnce of these functional antibodies between groups. The persistently seropositive group was further divided into non-AIDS and AIDS groups according to clinical status at serum collection. The ADCC antibody frequencies were much higher (70%) in the non-AIDS group than the AIDS group (30%). Of the non-AIDS children, 63% had neutralizing antibodies; no children with AIDS had these antibodies. HIV-specific ADCC and neutralizing antibodies do not seem to protect against transmission of HIV from mother to child but are significantly correlated with a better clinical stage of childhood HIV infection.