Pulmonary and aortic blood flow measurements in normal subjects and patients after single lung transplantation at 0.5 T using velocity encoded cine MRI
Pulmonary and aortic blood flow measurements in normal subjects and patients after single lung transplantation at 0.5 T using velocity encoded cine MRI
复制标题
DOI：
10.1378/chest.114.3.771
复制
发表时间：
1998-09-01
期刊：
影响因子：
9.6
通讯作者：
Mostbeck, GH
中科院分区：
文献类型：
--
作者：
Henk, CB;Schlechta, B;Mostbeck, GH
目的：本研究的目的是比较单肺移植（SLTX）患者与志愿者的肺和主动脉血流测量结果。方法/材料：对9例SLTX术后患者（男3名，女6名）和9名志愿者（男7名，女2名），在0.5 t设备（Philips Gyroscan: Best，荷兰）上分别对升主动脉、主肺动脉、轻肺动脉和左肺动脉进行垂直于血狮方向的双斜相对比造影- mri序列(重复时间600 ~ 800 ms，回声时间8 ms， alpha = 30；视场= 280 mm矩阵，128 x 256，心电门控，时间分辨率IG时间框架/RR间隔)。一项初步的体外研究使用相同的序列在非搏动流模型上显示，MRI测量的现在速度和流量与真实速度和流量之间具有良好的相关性（r = 0.99）。测量各血管的血流量（mL/min）、峰值平均收缩速度、阻力指数和扩张指数。结果：我们发现在正常志愿者（r = 0.95）和患者（r = 0.91）中，通过速度编码电影磁共振成像（VEC-MRI）在升主动脉和肺动脉主动脉中测量左心输出量和轻心输出量之间存在极好的相关性。在志愿者中进行的肺血狮鉴别测量显示，55%的右心输出量流向右肺，45%流向左肺。患者肺血流差异显示大部分血流量（81%）到达移植肺，仅有19%到达患者自身肺(SLTX: 4.5 +/- 1.8 L/min，患者自身肺：1.2 +/- 0.8 L/min)，正常志愿者与患者、患者自身肺与移植肺的峰值平均收缩速度和阻力指数差异均有统计学意义（p < 0.05）。结论：VEC-MRI血流量测量是监测SLTX术后肺血流动力学变化的一种有希望的无创工具。
Purpose: It is the purpose of this study to compare pulmonary and aortic blood flow measurements obtained in patients after single lung transplantation (SLTX) with those in volunteers.Methods/material: In nine patients after SLTX (three male, six female) and nine volunteers (seven male, two female), double oblique phase contrast cine-MRI sequences perpendicular to the direction of blood lion were obtained in the ascending aorta, main, light, and left pulmonary artery on a 0.5-T unit (Philips Gyroscan: Best, the Netherlands) (repetition time, 600 to 800 ms; echo time, 8 ms; alpha = 30; field of view = 280 mm matrix, 128 x 256, ECG gating, temporal resolution IG time frames/RR interval), An initial in vitro study using the same sequence on a nonpulsatile flow phantom showed excellent correlation (r = 0.99) between MRI measurements of now velocity and flow volume and true velocity and flow volume. Measurements of blood flow volume (mL/min), peak mean systolic velocity, resistive index, and distensibility index were obtained in each vessel.Results: We found excellent correlations between left and light cardiac output as measured by velocity encoded cine-MRI (VEC-MRI) in the ascending aorta and main pulmonary artery both in normal volunteers (r = 0.95) and in patients (r = 0.91). Differential pulmonary blood lion measurements in volunteers showed that 55% of the right cardiac output was directed to the right and 45% to the left lung. Differential pulmonary blood flow in patients showed that most of the blood flow (81%) reaches the transplanted lung and only 19% reaches the patient's own lung (SLTX: 4.5 +/- 1.8 L/min, patient's own lung: 1.2 +/- 0.8 L/min), There were significant differences (p < 0.05) in peak mean systolic velocity and resistive index obtained in the pulmonary arteries, both between normal volunteers and patients and between measurements obtained in the patient's own lung and the transplanted lung,Conclusion: VEC-MRI blood flow measurements are a promising noninvasive tool to monitor the hemodynamic changes of pulmonary blood flow after SLTX.