Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s.
Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s.
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DOI：
10.1084/jem.187.1.129
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发表时间：
1998-01-05
影响因子：
15.3
通讯作者：
Sinigaglia, F
中科院分区：
文献类型：
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作者：
Bonecchi, R;Bianchi, G;Bordignon, P P;D'Ambrosio, D;Lang, R;Borsatti, A;Sozzani, S;Allavena, P;Gray, P A;Mantovani, A;Sinigaglia, F
产生干扰素-γ的1型T辅助细胞（Th 1）主要介导细胞免疫应答，并参与慢性炎性病症的发展，而产生大量IL-4和IL-5的Th 2上调IgE产生，并在过敏性疾病的发病机制中突出。确定Th 1或Th 2介导的免疫应答是否优先发生在抗原暴露的外周部位的精确因素在很大程度上是未知的。趋化因子是多肽介体的超家族，是白细胞募集过程的关键组分。在这里，我们报告，在四个CXC（CXCR 1 -4）和五个CC（CCR 1 -5）趋化因子受体分析，CXCR 3和CCR 5优先表达在人类Th 1。相反，Th 2优先表达CCR 4，并且在较小程度上表达CCR 3。与差异趋化因子受体表达一致，Th 1和Th 2选择性地响应于相应的趋化因子而迁移。趋化因子受体的差异表达可能在很大程度上决定了Th 1和Th 2的迁移和组织归巢。它也可以确定不同的Th 1和Th 2的人类免疫缺陷病毒株使用不同的融合共受体的易感性。
T helper cells type 1 (Th1s) that produce interferon-γ predominantly mediate cellular immune responses and are involved in the development of chronic inflammatory conditions, whereas Th2s which produce large amounts of IL-4 and IL-5 upregulate IgE production and are prominent in the pathogenesis of allergic diseases. The precise factors determining whether Th1- or Th2-mediated immune responses preferentially occur at a peripheral site of antigen exposure are largely unknown. Chemokines, a superfamily of polypeptide mediators, are a key component of the leukocyte recruitment process. Here we report that among four CXC (CXCR1-4) and five CC (CCR1-5) chemokine receptors analyzed, CXCR3 and CCR5 are preferentially expressed in human Th1s. In contrast, Th2s preferentially express CCR4 and, to a lesser extent, CCR3. In agreement with the differential chemokine receptor expression, Th1s and Th2s selectively migrate in response to the corresponding chemokines. The differential expression of chemokine receptors may dictate, to a large extent, the migration and tissue homing of Th1s and Th2s. It may also determine different susceptibility of Th1s and Th2s to human immunodeficiency virus strains using different fusion coreceptors.