An Optical Nanoruler Based on a Conjugated Polymer-Silver Nanoprism Pair for Label-Free Protein Detection
An Optical Nanoruler Based on a Conjugated Polymer-Silver Nanoprism Pair for Label-Free Protein Detection
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基于共轭聚合物-银纳米棱镜对的光学纳米尺，用于无标记蛋白质检测
DOI：
10.1002/adma.201502880
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发表时间：
2015-10-21
影响因子：
29.4
通讯作者：
Wang, Shu
中科院分区：
文献类型：
--
作者：
Wang, Xiaoyu;Li, Shengliang;Wang, Shu
利用银纳米结构的金属增强荧光效应，研制了一种基于共轭聚电解质-银纳米棱镜对的光学纳米仪系统，用于无标记蛋白质检测。抗体-抗原相互作用诱导金属-荧光团距离的变化，随后是共轭多电解质的荧光信号的响应。该系统用于敏感和选择性地检测目标抗原。
An optical nanoruler system based on a conjugated polyelectrolyte-silver nanoprism pair is developed for label-free protein detection by taking advantage of the metal-enhanced fluorescence effect of silver nanostructures. Antibody-antigen interactions induce a change in the metal-fluorophore distance, followed by the response of a fluorescent signal of the conjugated polyelectrolyte. The system is used to detect target antigens sensitively and selectively.