SELECTIVE RADIATION-THERAPY IN STAGE-IB UTERINE CERVICAL-CARCINOMA FOLLOWING RADICAL PELVIC-SURGERY
SELECTIVE RADIATION-THERAPY IN STAGE-IB UTERINE CERVICAL-CARCINOMA FOLLOWING RADICAL PELVIC-SURGERY
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DOI：
10.1016/0090-8258(80)90068-2
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发表时间：
1980-01-01
影响因子：
4.7
通讯作者：
DISAIA, PJ
中科院分区：
文献类型：
--
作者：
ABDULHAYOGLU, G;RICH, WM;DISAIA, PJ
对35例IB期宫颈鳞状细胞癌患者行根治性子宫切除术及双侧盆腔淋巴结清扫术，分析其宫颈间质浸润深度、肿瘤分化程度、肿瘤血管浸润及淋巴结累及等组织病理因素。研究了这些因素对结果的影响。相关研究发现，宫颈间质浸润深度越深，淋巴结受累的风险越大，阴性淋巴结患者的复发风险也越大。2级和3级病变多见于宫颈外1/3间质浸润的患者，而血管肿瘤浸润仅见于宫颈中，且多见于宫颈外1/3间质浸润的患者。描述了一个亚组患者，他们在手术后疾病复发的风险很高，可能从辅助放射治疗中受益。
Patients (35) with squamous cell cancer of the cervix, stage IB, treated by radical hysterectomy and bilateral pelvic lymph node dissection are analyzed for histopathologic factors including depth of cervical stromal invasion, degree of differentiation of the tumor, vascular tumor invasion and lymph node involvement. The influence of these factors on the outcome is studied. A correlation is found in that the advanced depth of cervical stromal invasion appears to increase the risk of nodal involvement and also the subsequent recurrence in patients with negative nodes. The grade 2 and grade 3 disease is more often present in patients with outer 1/3 cervical stromal invasion, while the vascular tumorous invasion was only found in patients with middle and mostly with outer 1/3 cervical stromal invasion. A subgroup of patients is described, who are at high risk for recurrent disease following surgery and who may benefit from adjuvant radiation therapy.