Can anything be done to maintain the effectiveness of pyrethroid-impregnated bednets against malaria vectors?
Can anything be done to maintain the effectiveness of pyrethroid-impregnated bednets against malaria vectors?
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DOI：
10.1098/rstb.1998.0329
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发表时间：
1998-10-29
期刊：
影响因子：
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通讯作者：
Kasumba, I
中科院分区：
文献类型：
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作者：
Curtis, CF;Miller, JE;Kasumba, I
用拟除虫菊酯处理过的蚊帐是在热带世界控制疟疾最有希望的方法。应尽一切努力寻找应对或预防按蚊病媒对拟除虫菊酯产生抗药性的方法。这种抵抗的一些情况是已知的，特别是在An。西非的冈比亚，在那里选择了kdr类型的抗性，可能是因为在棉花上使用了拟除虫菊酯。由于拟除虫菊酯对蚊子具有刺激性，因此需要在尽可能真实的条件下，对自由飞翔的蚊子进行关于抗药性影响和抗药性选择的实验室研究。此类研究开始表明，尽管对所有拟除虫菊酯都存在交叉耐药性，但某些治疗方法选择耐药性的可能性低于其他治疗方法。有机磷、氨基甲酸酯和苯基吡唑杀虫剂已作为蚊帐或窗帘的替代处理方法进行了试验。已经尝试将昆虫生长调节剂和拟除虫菊酯在网上混合以使在与网接触后未被杀死的拟除虫菊酯抗性蚊子灭菌。拟除虫菊酯抗性管理问题似乎没有简单的解决办法，但迫切需要进一步的研究。
Pyrethroid-treated bednets are the most promising available method of controlling malaria in the tropical world. Every effort should be made to find methods of responding to, or preventing, the emergence of pyrethroid resistance in the Anopeles vectors. Some cases of such resistance are known, notably in An. gambiae in West Africa where the kdr type of resistance has been selected, probably because of the use of pyrethroids on cotton. Because pyrethroids are irritant to mosquitoes, laboratory studies on the impact of, and selection for, resistance need to be conducted with free-flying mosquitoes in conditions that are as realistic as possible. Such studies are beginning to suggest that, although there is cross-resistance to all pyrethroids, some treatments are less likely to select for resistance than others are. Organophosphate, carbamate and phenyl pyrazole insecticides have been tested as alternative treatments for nets or curtains. Attempts have been made to mix an insect growth regulator and a pyrethroid on netting to sterilize pyrethroid-resistant mosquitoes that are not killed after contact with the netting. There seems to be no easy solution to the problem of pyrethroid resistance management, but further research is urgently needed.