Demonstration of "owl's eye" morphology by confocal microscopy in a patient with presumed cytomegalovirus corneal endotheliitis
Demonstration of "owl's eye" morphology by confocal microscopy in a patient with presumed cytomegalovirus corneal endotheliitis
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DOI：
10.1016/j.ajo.2006.11.026
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发表时间：
2007-04-01
影响因子：
4.2
通讯作者：
Ohashi, Yuichi
中科院分区：
文献类型：
--
作者：
Shiraishi, Atsushi;Hara, Yuko;Ohashi, Yuichi
目得：报道一名疑似巨细胞病毒（CMV）角膜内皮炎患者特征性角膜内皮病变的共聚焦显微镜观察结果。设计：病例报告。方法：一名77岁的免疫功能正常的男性因角膜水肿、角膜沉淀物和右眼硬币状病变入院。共聚焦显微镜检查角膜内皮细胞。结果：PCR法检测到CMV DNA。共聚焦显微镜显示大的角膜内皮细胞，在细胞核中有一个高反射区，周围有一个低反射晕。这种“猫头鹰眼”的形态是CMV感染的特征。局部和静脉内，更昔洛韦治疗导致角膜沉淀物和水肿的快速解决，随后消失的猫头鹰的眼睛morphology.CONCLUSIONS：共聚焦显微镜可以检测到猫头鹰的眼睛形态在假定CMV角膜内皮炎患者的角膜内皮。
PURPOSE: To report confocal microscopic observations of characteristic corneal endothelial lesions in a patient with presumed cytomegalovirus (CMV) corneal endotheliitis.DESIGN: Case report.METHODS: A 77-year-old, immunocompetent man was admitted with corneal edema, keratic precipitates, and coin,shaped lesions in the right eye. Confocal microscopy was performed to examine the corneal endothelium. Polymerase chain reaction (PCR) was used to identify viral DNA in an aqueous humor sample.RESULTS: CMV DNA was detected by PCR. Confocal microscopy showed large corneal endothelial cells with an area of high reflection in the nucleus surrounded by a halo of low reflection. This "owl's eye" morphology is characteristic of CMV infection. Topical and intra, venous ganciclovir treatment resulted in rapid resolution of the corneal precipitates and edema, followed by disappearance of the owl's eye morphology.CONCLUSIONS: Confocal microscopy can detect the owl's eye morphology in the corneal endothelium of patients with presumed CMV corneal endotheliitis.