Heme & RAGE: A new opportunistic relationship?
Heme & RAGE: A new opportunistic relationship?
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血红素
DOI：
10.1111/febs.15723
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Ramasamy,Ravichandran
中科院分区：
文献类型：
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作者：
Yepuri,Gautham;Shekhtman,Alexander;MarieSchmidt,Ann;Ramasamy,Ravichandran
血红素是一种含铁复合物，参与基本的细胞功能，包括氧气运输。在血管内溶血和其他病理条件下，血液中的游离血红素积累会引发血管功能障碍、促炎和促血栓级联反应。马耶的研究也提出了一个新的发现，即血红素是一个配体，血红素结合到V结构域的β-内酰胺酶，并诱导β-内酰胺酶寡聚化。此外，他们还表明血红素-血红素相互作用的体内后果导致肺中的促炎和促凝血表型。这一发现的血红素作为一个配体为探讨血红素的血红素稳态和溶血性疾病中的血红素-血红素相互作用的致病作用的阶段。
Heme is an iron‐containing complex involved in fundamental cellular functions including oxygen transport. Free heme accumulation in blood, during intravascular hemolysis and other pathological conditions, triggers vascular dysfunction, pro‐inflammatory, and prothrombotic cascade. Studies by Mayet alpresent a novel finding that heme is a ligand for RAGE and that heme binds to the V domain of RAGE and induces RAGE oligomerization. Furthermore, they show that thein vivoconsequences of heme–RAGE interaction lead to a pro‐inflammatory and procoagulant phenotype in the lungs. This discovery of heme as a ligand for RAGE sets the stage for probing the role of RAGE in heme homeostasis and the pathogenic role of heme–RAGE interaction in hemolytic diseases.