Food intake patterns and 25-year mortality from coronary heart disease: Cross-cultural correlations in the Seven Countries Study
Food intake patterns and 25-year mortality from coronary heart disease: Cross-cultural correlations in the Seven Countries Study
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DOI：
10.1023/a:1007529206050
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发表时间：
1999-07-01
影响因子：
13.6
通讯作者：
Nissinen, A
中科院分区：
文献类型：
--
作者：
Menotti, A;Kromhout, D;Nissinen, A
在七国研究中，研究了食物摄入量与冠心病（CHD，定义为冠心病猝死或致命性心肌梗死）25年死亡率之间的关系。基线调查是在1958年至1964年期间进行的。在7个国家（美国、芬兰、荷兰、意大利、前南斯拉夫、希腊和日本）的16个队列的12,763名中年男性中测量了一些个人特征。采用称重记录法收集子样本中的膳食信息。在25年的随访期间，定期验证所有参与者的生命状态，并裁定潜在的死亡原因。考虑了18种不同的食物组和组合，用于队列之间的比较。不同食物组的消费量差异很大，北方欧洲的乳制品消费量较高，美国的肉类消费量较高，南欧的蔬菜、豆类、鱼类和葡萄酒消费量较高，日本的谷物、豆制品和鱼类消费量较高。冠心病的人口死亡率差异很大，从芬兰东部的268/1000到希腊克里特岛的25/1000。动物性食物组与冠心病死亡率直接相关，蔬菜性食物组（土豆除外）以及鱼和酒精与冠心病死亡率呈负相关。单变量分析显示黄油（R = 0.887）、肉类（R = 0.645）、糕点（R = 0.752）和牛奶（R = 0.600）的消费量呈显著正相关，豆类（R = -0.822）、油类（R = -0.571）和酒精（R = -0.609）的消费量呈显著负相关。蔬菜类食物（不含酒精）与冠心病死亡率呈负相关（R = -0.519），而动物类食物（不含鱼类）与冠心病死亡率呈正相关（R = 0.798）。多元逐步分析选择黄油，猪油+人造黄油和肉类作为显着的预测因子，并产生了R-2为0.922。这些发现得到了因子分析的证实。这些跨文化分析与饮食模式是人群CHD死亡率差异的重要决定因素的假设一致，并证实了动物和植物性食物对明显风险的相反影响。
In the Seven Countries Study, associations between the intake of food-groups and 25-year mortality from coronary heart disease (CHD, defined as sudden coronary death or fatal myocardial infarction) were investigated. Baseline surveys were carried out between 1958 and 1964. A number of individual characteristics were measured in 12,763 middle-aged men belonging to 16 cohorts in seven countries (USA, Finland, The Netherlands, Italy, former Yugoslavia, Greece and Japan). Dietary information was collected in sub-samples using the weighed record method. Vital status of all participants was verified at regular intervals during 25 years of follow-up and the underlying cause of death was adjudicated. Eighteen different food-groups and combinations were considered for comparison among cohorts. Large differences in food-group consumption were seen, with high consumption of dairy products in Northern Europe, meat in the USA, vegetables, legumes, fish, and wine in Southern Europe, and cereals, soy products, and fish in Japan. Population death rates from CHD showed large differences, ranging from 268 per 1000 in East Finland to 25 per 1000 in Crete, Greece. Animal food-groups were directly correlated, and vegetable food-groups (except potatoes) as well as fish and alcohol were inversely correlated with CHD mortality. Univariate analysis showed significant positive correlation coefficients for butter (R = 0.887), meat (R = 0.645), pastries (R = 0.752), and milk (R = 0.600) consumption, and significant negative correlation coefficients for legumes (R = -0.822), oils (R = -0.571), and alcohol (R = -0.609) consumption. Combined vegetable foods (excluding alcohol) were inversely correlated (R = -0.519), whereas combined animal foods (excluding fish) were directly correlated (R = 0.798) with CHD death rates. Multivariate stepwise analysis selected butter, lard+margarine and meat as significant predictors and produced an R-2 of 0.922. These findings were confirmed by factor analysis. These cross-cultural analyses are consistent with the hypothesis that dietary patterns are important determinants of differences in population CHD death rates, and confirm the opposite effects on apparent risk of animal and vegetable foods.