Double network hydrogel with high mechanical strength: Performance, progress and future perspective
Double network hydrogel with high mechanical strength: Performance, progress and future perspective
复制标题
具有高机械强度的双网络水凝胶：性能、进展和未来展望
DOI：
10.1007/s11431-012-4857-y
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发表时间：
2012-08-01
影响因子：
4.6
通讯作者：
Xu Feng
中科院分区：
文献类型：
--
作者：
Chen YongMei;Dong Kun;Xu Feng
双网络（DN）水凝胶具有高的含水量（接近90wt%）和显著改善的机械强度（接近MPa），已成为在生物医学中具有广泛应用的有前途的生物材料。近年来，具有极高机械强度的DN水凝胶取得了很大的进展，科学家们设计了一系列具有低摩擦、低磨损、机械各向异性和细胞相容性等新功能的天然和仿生DN水凝胶。这些进展还导致了用于组织如软骨再生的生物相容性DN水凝胶的新设计。本文综述了高强度DN水凝胶的设计策略，并分析了影响DN水凝胶性能的因素。我们还讨论了DN水凝胶的挑战和未来的发展，鉴于其作为生物材料的生物医学应用的潜力。
With high water content (similar to 90 wt%) and significantly improved mechanical strength (similar to MPa), double network (DN) hydrogels have emerged as promising biomaterials with widespread applications in biomedicine. In recent years, DN hydrogels with extremely high mechanical strength have achieved great advance, and scientists have designed a series of natural and biomimetic DN hydrogels with novel functions including low friction, low wear, mechanical anisotropy and cell compatibility. These advances have also led to new design of biocompatible DN hydrogels for regeneration of tissues such as cartilage. In this paper, we reviewed the strategies of designing high-strength DN hydrogel and analyzed the factors that affect DN hydrogel properties. We also discussed the challenges and future development of the DN hydrogel in view of its potential as biomaterials for their biomedical applications.