Ultrastructure of abnormal collagen in human tumors.
Ultrastructure of abnormal collagen in human tumors.
复制标题
人类肿瘤中异常胶原蛋白的超微结构。
作者：
M. T. Hull;K. Warfel
透射电镜观察22例不同组织发生方式的人肿瘤中胶原原纤维异常。它们是在对1400个电子显微镜病例的审查中发现的。异常的胶原原纤维，被其他人描述为类氨基酸纤维、复合胶原、胶原花和纤维内胶原发育不良，很少在人类肿瘤中发现，但通常在某些结缔组织疾病中发现，如弹性假黄瘤、ehers - danlos综合征、马凡氏综合征、骨关节炎软骨和肺气肿性肺等。这里所描述的异常包括原纤维增厚、原纤维变性和不规则的外部轮廓。它们形成的机制包括可能由于缺氧或胶原酶活性、胶原生物合成异常和糖胺聚糖组织水平异常引起的变性。在这22例人类肿瘤中发现的异常胶原原纤维表明，它们的发生比以前发表的报道所表明的更为普遍。胶原原纤维异常的肿瘤多为间充质或软组织肿瘤。4例神经内分泌肿瘤胶原原纤维异常。
Abnormal collagen fibrils were identified by transmission electron microscopy in 22 human tumors of differing histogenesis. They were found in a review of 1400 electron microscopy cases. Abnormal collagen fibrils, described by others as amianthoid fibers, composite collagen, collagen flowers and intrafibrillar collagen dysplasia, have been found only rarely in human tumors but commonly in certain connective tissue diseases such as pseudoxanthoma elasticum, Ehlers-Danlos syndromes, Marfan's syndrome, osteoarthritic cartilage, and emphysematous lung among others. Abnormalities in the cases described here included thickened fibrils, fibrillar degeneration of fibrils and irregular external contours. Proposed mechanisms for their formation have included degeneration possibly due to hypoxia or collagenase activity, abnormal collagen biosynthesis, and abnormal tissue levels of glycosaminoglycans. The finding of abnormal collagen fibrils in these 22 human tumors shows that their occurrence is more common than is indicated by previous published reports. Most of the tumors containing abnormal collagen fibrils were mesenchymal or soft tissue tumors. Four neuroendocrine neoplasms had abnormal collagen fibrils.