Signaling mechanisms regulating Wallerian degeneration.
Signaling mechanisms regulating Wallerian degeneration.
复制标题
DOI：
10.1016/j.conb.2014.05.001
复制
发表时间：
2014-08
影响因子：
5.7
通讯作者：
Freeman MR
中科院分区：
文献类型：
--
作者：
Freeman MR
沃勒变性（WD）发生在轴突被切割或压碎之后，并且需要损伤部位远端的切断的轴突的解体和清除。WD最初被认为是由于远端轴突片段的被动消耗，大概是因为它缺乏来自细胞体的营养供应。缓慢沃勒变性（Wlds）突变小鼠的发现，其中远端切断的轴突完整存活数周而不是仅1-2天，从根本上改变了我们对轴突生存自主性的看法。Wlds告诉我们，在某些条件下，轴突隔室可以在没有细胞体的情况下在轴突切开后存活数周。Wlds的表型和分子特征以及Wlds分子功能的当前模型进行了综述，但Wlds保留切断轴突的机制仍未解决。然而，最近的研究启发Wlds导致第一个“轴突死亡”的信号分子，其内源性活动促进轴突破坏在WD的鉴定。
Wallerian degeneration (WD) occurs after an axon is cut or crushed and entails the disintegration and clearance of the severed axon distal to the injury site. WD was initially thought to result from the passive wasting away of the distal axonal fragment, presumably because it lacked a nutrient supply from the cell body. The discovery of the slow Wallerian degeneration (Wlds) mutant mouse, in which distal severed axons survive intact for weeks rather than only 1–2 days, radically changed our thoughts on the autonomy of axon survival. Wlds taught us that under some conditions the axonal compartment can survive for weeks after axotomy without a cell body. The phenotypic and molecular characterization of Wlds and current models for Wlds molecular function are reviewed herein—the mechanism(s) by which WldS spares severed axons remains unresolved. However, recent studies inspired by Wlds have led to the identification of the first “axon death” signaling molecules whose endogenous activities promote axon destruction during WD.
登录
查看更多内容
影响因子：
9.2
作者：
Ferri, A;Sanes, JR;Kato, AC
通讯作者：
Kato, AC
影响因子：
15.3
作者：
Kim, Younghwa;Zhou, Ping;Ding, Aihao
通讯作者：
Ding, Aihao
影响因子：
5.3
作者：
Babetto, Elisabetta;Beirowski, Bogdan;Coleman, Michael P.
通讯作者：
Coleman, Michael P.
DOI：
10.1073/pnas.95.17.9985
发表时间：
1998-08-18
影响因子：
11.1
作者：
Coleman, MP;Conforti, L;Perry, VH
通讯作者：
Perry, VH
DOI：
10.1523/jneurosci.4065-10.2011
发表时间：
2011-01-19
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Barrientos SA;Martinez NW;Yoo S;Jara JS;Zamorano S;Hetz C;Twiss JL;Alvarez J;Court FA
通讯作者：
Court FA