The atrial natriuretic factor: its physiology and biochemistry.
The atrial natriuretic factor: its physiology and biochemistry.
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DOI：
10.1007/bfb0027530
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
J. Genest;M. Cantin
中科院分区：
文献类型：
--
作者：
J. Genest;M. Cantin
在医学研究史上，自从De Bold等人最初的观察以来，在心钠素的研究方面，很少有哪项进展在所有方面都比这些研究进展得更快。1981年，静脉注射粗心耳提取物后，出现明显的利钠、利尿和血管松弛。导致这些发现的心房因子已经被分离和测序，编码ANF的基因已经被克隆，该基因已经定位在染色体图谱上。它的大部分生物活性已经被确定，这些显然为肾素血管紧张素系统的活性提供了平衡。许多问题仍有待阐明，如ANF在高血压合并充血性心力衰竭患者中的作用；室性ANF参与高血压和充血性心力衰竭等病理状态的作用；ANF和血管紧张素II在脑内参与钠、水和血压调节的区域(如AV3V区和穹隆下器官)的相互作用；ANF在眼睛睫状体的作用；微粒鸟苷晚期环化酶刺激和腺苷环化酶抑制与血管松弛的关系；ANF在神经传递中的神经调节作用；以及许多其他的问题。基本问题仍有待回答，并为创新研究提供了一个领域。
In the history of medical research, few advances have been more rapid — in all aspects — than those in the research on the atrial natriuretic factor since the original observation by de Bold et al. in 1981 of the marked natriuresis, diuresis, and vasorelaxation following the i. v. administration of crude atrial extracts. The atrial factor responsible for these findings has been isolated and sequenced, the cDNA coding for ANF has been cloned, and the gene has been localized on the chromosomal map. Most of its biological activities have been determined, and these clearly provide a balance to the activities of the reninangiotensin system. Many points remain to be elucidated, such as the role of ANF in patients with essential hypertension with congestive heart failure; the participation of ventricular ANF in pathological states such as hypertension and congestive heart failure; the interplay of ANF and angiotensin II in brain regions involved in the regulation of sodium, water, and blood pressure such as the AV3V region and the subfornical organ; the role of ANF in the ciliary bodies of the eyes; the relationship of particulate guanylate cyclase stimulation and adenylate cyclase inhibition with vasorelaxation; the neuromodulatory role of ANF in neural transmission; and many others. Fundamental questions remain to be answered and offer a field for innovative researches.