The relation between the clinical subtypes of delirium and the urinary level of 6-SMT
The relation between the clinical subtypes of delirium and the urinary level of 6-SMT
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DOI：
10.1176/appi.neuropsych.15.3.363
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发表时间：
2003-06-01
影响因子：
2.9
通讯作者：
Habot, B
中科院分区：
文献类型：
--
作者：
Balan, S;Leibovitz, A;Habot, B
谵妄是老年住院患者的常见症状。在人类中，睡眠和昼夜节律在谵妄期间受到干扰，两者都受到褪黑激素的影响。这促使我们研究谵妄的临床亚型：1)多动型，2)低动型，3)混合型，与褪黑素的关系，这是由患者尿液代谢物6-SMT反映的。结果支持我们的假设，即谵妄期间尿6-SMT在低活动患者中较高，在多活动患者中较低。由于这是首次报道与谵妄临床亚型相关的生化参数，因此有必要进一步研究褪黑素与谵妄之间的联系。
Delirium is a common syndrome among hospitalized elderly patients. In humans, sleep and circadian rhythms are disturbed during delirium, and both are influenced by the hormone melatonin. This prompted us to investigate the relationship of the clinical subtypes of delirium: 1) hyperactive, 2) hypoactive, and 3) mixed, with melatonin, as reflected by a patient's urinary metabolite 6-SMT. Results support our hypothesis that urinary 6-SMT during delirium was higher in hypoactive and lower in hyperactive patients. Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.