EFFECTS OF ALPHA-ADRENOCEPTOR AGONISTS AND ANTAGONISTS IN A MAZE-EXPLORATION MODEL OF FEAR-MOTIVATED BEHAVIOR
EFFECTS OF ALPHA-ADRENOCEPTOR AGONISTS AND ANTAGONISTS IN A MAZE-EXPLORATION MODEL OF FEAR-MOTIVATED BEHAVIOR
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DOI：
10.1007/bf00504983
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发表时间：
1984-01-01
影响因子：
3.6
通讯作者：
MITHANI, S
中科院分区：
文献类型：
--
作者：
HANDLEY, SL;MITHANI, S
以高架X-迷宫为模型，研究了开放臂和封闭臂交替的恐惧诱导行为。抗抑郁药（地西泮和淀粉巴比妥）增加，假定的抗焦虑药（ACTH和印防己毒素）减少开放臂条目的比例。α 1-肾上腺素能受体激动剂，苯异丙基肾上腺素和ST 587（2-（2-氯-5-三氟甲基苯基亚氨基）咪唑烷），和α 2-肾上腺素能受体拮抗剂，咪唑克生，哌珀生，RS-21361 [2-[（2，3-二氢-1，4-苯并二氧杂环己烯-2-基）甲基]-1-乙基-1H-咪唑]和育亨宾，减少了相对的开臂进入，类似于推定的致焦虑药。阿塞泊索、可乐定和胍那苄、α 2-肾上腺素受体激动剂和α 1-肾上腺素受体拮抗剂哌唑嗪和胸腺嘧啶在低剂量下提高了开放臂进入的比例，表明抗焦虑样性质。这些药物在较高剂量时出现开放臂入组的反常下降。去甲肾上腺素能系统参与了恐惧动机的行为。
An elevated X-maze with alternating open and enclosed arms was investigated as a fear-induced behavior model. Anxiolytics (diazepam and amylobarbitone) increased and putative anxiogenics (ACTH and picrotoxin) decreased the proportion of open arm entries. The .alpha.1-adrenoceptor agonists, phenylephrine and ST587 (2-(2-chloro-5-trifluoromethylphenylimino)imidazolidine), and the .alpha.2-adrenoceptor antagonists, idazoxan, piperoxane, RS-21361 [2-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-ethyl-1H-imidazole] and yohimbine, decreased relative open-arm entries, resembling the putative anxiogenics. Azepexole, clonidine and guanabenz, .alpha.2-adrenoceptor agonists, and the .alpha.1-adrenoceptor antagonists, prazosin and thymoxamine, enhanced the proportion of open arm entries at low doses, suggesting anxiolytic-like properties. A paradoxical fall in open arm entries occurred with these agents at higher doses. The involvement of noradrenergic systems in fear-motivated behavior was shown.