Coupling of D1 dopamine receptors to the guanine nucleotide binding protein Gs is deficient in Huntington's disease
Coupling of D1 dopamine receptors to the guanine nucleotide binding protein Gs is deficient in Huntington's disease
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亨廷顿病中 D1 多巴胺受体与鸟嘌呤核苷酸结合蛋白 Gs 的偶联存在缺陷
DOI：
10.1016/0006-8993(89)91082-2
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发表时间：
1989
期刊：
影响因子：
2.9
通讯作者：
G. Vauquelin
中科院分区：
文献类型：
--
作者：
J. Keyser;J. Backer;G. Ebinger;G. Vauquelin
人脑含有两种亚型的D1多巴胺受体，它们都存在于高（RH）和低激动剂亲和力（RL）位点，但可以根据GTP将RH转化为RL的能力来区分。杏仁核仅含有GTP敏感（GS）D1受体，额叶皮层仅含有GTP不敏感（GI）D1受体，壳核含有GS和GI受体。与对照组相比，我们无法检测到RH网站在杏仁核患者的亨廷顿病（HD）。正常和HD额叶皮质RH位点的数量相似。在壳核中，GTP诱导的RH部分转化为RL，在对照组中观察到，在HD中不存在。结果表明，GS-D1受体与鸟嘌呤核苷酸结合蛋白Gs的偶联可能在HD中缺乏。
Human brain contains two subtypes of D1dopamine receptors, which both exist under high- (RH) and low-agonist affinity (RL) sites, but can be distinguished on the basis of the ability of GTP to convert RH into RL. The amygdala contains exclusively GTP-sensitive (GS) D1receptors, frontal cortex exclusively GTP-insensitive (GI) D1receptors, and putamen both GS and GI receptors. In contrast with controls, we were unable to detect RH sites in amygdala from patients with Huntington disease (HD). The amount of RH sites in normal and HD frontal cortex were similar. In putamen, the GTP-induced partial conversion of RH into RL, observed in controls, was absent in HD. The results suggest that coupling of GS-D1receptors with the guanine nucleotide binding protein Gs may be deficient in HD.
DOI：
10.1056/nejm198611133152006
发表时间：
1986-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
J. B. Martin;J. Gusella
通讯作者：
J. B. Martin;J. Gusella