Thermal ablation of uterine fibroids using MR-guided focused ultrasound-a truly non-invasive treatment modality
Thermal ablation of uterine fibroids using MR-guided focused ultrasound-a truly non-invasive treatment modality
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DOI：
10.1007/s00330-007-0644-8
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发表时间：
2007-10-01
影响因子：
5.9
通讯作者：
ter Haar, Gail
中科院分区：
文献类型：
--
作者：
Chapman, Alexander;ter Haar, Gail
子宫肌瘤是育龄妇女发病率的重要来源。传统上，最终的治疗方法是子宫切除术，但越来越多的女性不准备接受这种良性且通常自限性的侵入性手术。虽然现在有许多微创技术可用，但聚焦超声具有相当大的优势，因为它是完全无创的，不需要麻醉。成像技术的改进，特别是磁共振成像（MRI），使治疗的精确规划、靶向和监测成为可能。我们回顾了聚焦超声手术治疗肌瘤的早期经验，特别是最近一期、二期和三期多中心临床试验的结果。这些试验和其他研究表明，核磁共振引导的聚焦超声消融是可行的，安全的，并且似乎具有与其他治疗方式相当的疗效。该技术具有非侵入性和可作为门诊手术的优点。
Uterine fibroids are a significant source of morbidity for women of reproductive age. Definitive treatment has traditionally been a hysterectomy, but increasingly women are not prepared to undergo such an invasive procedure for a benign and usually self-limiting condition. Although a number of minimally invasive techniques are now available, focused ultrasound has a considerable advantage over them as it is completely non-invasive and does not require an anaesthetic. Improvements in imaging techniques, particularly magnetic resonance imaging (MRI), have enabled the accurate planning, targeting and monitoring of treatments. We review the early experience of focused ultrasound surgery for the treatment of fibroids, and, in particular, the results of the recent phase I, II and III multi-centre clinical trials. These trials and other studies which demonstrate that MR-guided focused ultrasound ablation is feasible, safe and appears to have an efficacy that is comparable with other treatment modalities are described. This technique has the advantages of being non-invasive and being deliverable as an out-patient procedure.