Monitored daily ambulatory activity, inflammation, and oxidative stress in patients with claudication.

Monitored daily ambulatory activity, inflammation, and oxidative stress in patients with claudication.
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DOI:
10.1177/0003319713489769
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发表时间:
2014-07
期刊:
影响因子:
2.8
通讯作者:
Casanegra AI
Casanegra AI
中科院分区:
医学3区
文献类型:
--
作者:
Gardner AW;Parker DE;Montgomery PS;Blevins SM;Teague AM;Casanegra AI

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我们确定了外周动脉疾病(PAD)和跛行患者的每日步行活动与炎症和氧化应激标志物之间的关系。研究了局限于跛行的PAD患者(n=134)。患者每天步行3275±1743步,平均步行273±112分钟,平均步频为11.7±2.7步/分钟,超敏C反应蛋白与每日总步行数呈显著负相关(p<0.001),每日总门诊时间(p<0.01),峰值活动指数(p<0.01)、日平均踏频(p<0.05)、60 min(p<0.05)、30 min(p<0.05)、20 min(p<0.05)和5 min(p<0.01)的最大踏频。氧化型低密度脂蛋白和可溶性血管细胞粘附分子-1与任何动态指标均无显著相关性(p>0.05)。我们的结论是,更高水平的社区为基础的,日常活动与较低水平的炎症,但不与氧化应激标志物。
We determined the association between daily ambulatory activity and markers of inflammation and oxidative stress in patients with peripheral artery disease (PAD) and claudication. Patients with PAD (n=134) limited by claudication were studied. Patients took 3275±1743 daily strides during 273±112 min each day, and their average daily cadence was 11.7±2.7 strides/min. High-sensitivity C-reactive protein was significantly and negatively associated with the total number of daily strides (p<0.001), total daily ambulatory time (p<0.01), peak activity index (p<0.01), daily average cadence (p<0.05), and the maximum cadences for 60 min (p<0.05), 30 min (p<0.05), 20 min (p<0.05) and 5 min (p<0.01). Oxidized low density lipoprotein and soluble vascular cell adhesion molecule-1 were not significantly associated with any of the ambulatory measures (p>0.05). We conclude that higher levels of community-based, daily ambulatory activity are associated with lower levels of inflammation, but are not associated with markers of oxidative stress.
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