The effect of preoperative serum triglycerides and high-density lipoprotein-cholesterol levels on the prognosis of breast cancer
The effect of preoperative serum triglycerides and high-density lipoprotein-cholesterol levels on the prognosis of breast cancer
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术前血清甘油三酯和高密度脂蛋白胆固醇水平对乳腺癌预后的影响
DOI：
10.1016/j.breast.2016.11.024
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发表时间：
2017-04-01
期刊：
影响因子：
3.9
通讯作者：
Xie, Xiaoming
中科院分区：
文献类型：
--
作者：
Li, Xing;Tang, Hailin;Xie, Xiaoming
目的：虽然血脂异常已被证明与包括乳腺癌在内的几种癌症有关，但血脂在乳腺癌中的预后价值仍不确定。本研究旨在探讨乳腺癌患者术前血脂水平与预后的关系。（包括胆固醇[CHO];甘油三酯[TG]、高密度脂蛋白胆固醇[HDL-C]、低密度脂蛋白胆固醇[LDL-C]、载脂蛋白A-I [ApoAI]，方法回顾性分析1044例乳腺癌手术患者血清载脂蛋白（ApoB）、载脂蛋白B [ApoB]水平及临床资料。采用Kaplan-Meier法和考克斯比例风险回归模型分析总生存期（OS）和无病生存期（DFS）。结果：结合受试者手术特征和Kaplan-Meier分析，发现术前低TG和HDL-C水平是乳腺癌患者的危险因素。在多变量分析中，HDL-C水平降低与OS恶化显著相关（HR：0.528; 95% CI：0.302 - 0.923; P = 0.025），而TG水平降低与DFS恶化显著相关（HR：0.569; 95% CI：0.370-0.873; P = 0.010）。结论：术前血清TG、HDL-C水平可作为乳腺癌患者预后的独立预测因素。(C)2016爱思唯尔有限公司版权所有。
Objectives: Although dyslipidemia has been documented to be associated with several types of cancer including breast cancer, it remains uncertainty the prognostic value of serum lipid in breast cancer. The purpose of this study is to evaluate the association between the preoperative plasma lipid profile and the prognostic of breast cancer patients.Methods: The levels of preoperative serum lipid profile (including cholesterol [CHO]; Triglycerides [TG], high-density lipoprotein-cholesterol [HDL-C], low-density lipoprotein-cholesterol [LDL-C], apolipoprotein A-I [ApoAI], and apolipoprotein B [ApoB]) and the clinical data were retrospectively collected and reviewed in 1044 breast cancer patients undergoing operation. Kaplan-Meier method and the Cox proportional hazards regression model were used in analyzing the overall survival [OS] and disease-free survival [DFS].Results: Combining the receiver-operating characteristic and Kaplan-Meier analysis, we found that preoperative lower TG and HDL-C level were risk factors of breast cancer patients. In multivariate analyses, a decreased HDL-C level showed significant association with worse OS (HR: 0.528; 95% CI: 0.302 -0.923; P = 0.025), whereas a decreased TG level showed significant association with worse DFS (HR: 0.569; 95% CI: 0.370-0.873; P = 0.010). Conclusions: Preoperative serum levels of TG and HDL-C may be independent factor to predict outcome in breast cancer patient. (C) 2016 Elsevier Ltd. All rights reserved.