Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes
Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes
复制标题
DOI：
10.2337/dc05-2482
复制
发表时间：
2006-09-01
期刊：
影响因子：
16.2
通讯作者：
Shofer, Jane B.
中科院分区：
文献类型：
--
作者：
Carr, Darcy B.;Heckbert, Susan R.;Shofer, Jane B.
目的-我们试图确定是否有妊娠期糖尿病（GDM）的历史进一步增加了心血管疾病（CVD）的风险，在parous妇女与一级亲属与2型diabetes.Research设计和方法-妇女（n = 332）和没有（n = 663）的GDM的历史进行了比较：1）修订的国家胆固醇教育计划成人治疗小组III代谢综合征标准，2）2型糖尿病的患病率，和3）自我报告的心血管疾病。结果-“妇女与先前的GDM是年轻的（48.6 +/- 0.7 vs. 52.4 +/- 0.6年[平均值- SE]; P < 0.001），绝经后的可能性较小（48.3 vs. 57.9%; P < 0.005）。虽然两组都是肥胖的（BMI 34.4 +/- 1.2 vs. 33.7 +/- 0.6 kg/m2），但有GDM病史的妇女更容易患代谢综合征（86.6 vs. 73.5%; P < 0.001）和2型糖尿病（93.4% vs. 63.3%; P < 0.001）。此外，他们有更高的心血管疾病患病率，（15.5 vs. 12.4%;校正比值比1.85 [95% CI 1.21-2.82]; P = 0.005），发生在较年轻的年龄（45.5 ± 2.2 vs. 52.5 ± 1.9岁; P = 0.02），与代谢综合征无关（1.74 [1.10-2.76]; P = 0.02）和2型糖尿病（1.56 [1.002-2.43];结论：在有2型糖尿病家族史的女性中，那些既往患有GDM的女性更有可能不仅有CVD危险因素，包括代谢综合征和2型糖尿病，而且经历过CVD事件，发生在年轻时。因此，同时具有2型糖尿病家族史和GDM个人史的女性可能特别适合进行旨在预防或降低其CVD和糖尿病风险的早期干预。
OBJECTIVE - We sought to determine whether a history of gestational diabetes mellitus (GDM) further increases the risk of cardiovascular disease (CVD) in parous women with first-degree relatives with type 2 diabetes.RESEARCH DESIGN AND METHODS - Women with (n = 332) and without (n = 663) a history of GDM were compared regarding 1) the revised National Cholesterol Education Program Adult Treatment Panel III metabolic syndrome criteria, 2) the prevalence of type 2 diabetes, and 3) self-reported CVD.RESULTS -' Women with prior GDM were younger (48.6 +/- 0.7 vs. 52.4 +/- 0.6 years [means - SE]; P < 0.001) and less likely to be postmenopausal (48.3 vs. 57.9%; P < 0.005). Although both groups were obese (BMI 34.4 +/- 1.2 vs. 33.7 +/- 0.6 kg/m(2)), women with prior GDM were more likely to have metabolic syndrome (86.6 vs. 73.5%; P < 0.001) and type 2 diabetes (93.4% vs. 63.3%; P < 0.001). Moreover, they had a higher prevalence of CVD (15.5 vs. 12.4%; adjusted odds ratio 1.85 [95% CI 1.21-2.82]; P = 0.005) that occurred at a younger age (45.5 +/- 2.2 vs. 52.5 +/- 1.9 years; P = 0.02) and was independent of metabolic syndrome (1.74 [1.10-2.76]; P = 0.02) and type 2 diabetes (1.56 [1.002-2.43]; P < 0.05).CONCLUSIONS - Among women with a family history of type 2 diabetes, those with prior GDM were even more likely to not only have CVD risk factors, including metabolic syndrome and type 2 diabetes, but also to have experienced CVD events, which occurred at a younger age. Thus, women with both a family history of type 2 diabetes and personal history of GDM may be especially suitable for early interventions aimed at preventing or reducing their risk of CVD and diabetes.