Review: unraveling Lyme disease.

Review: unraveling Lyme disease.
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DOI:
10.1002/art.38756
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发表时间:
2014-09
影响因子:
13.3
通讯作者:
Wormser, Gary P.
Wormser, Gary P.
中科院分区:
医学1区
文献类型:
--
作者:
Bockenstedt, Linda K.;Wormser, Gary P.

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莱姆病由广义伯氏疏螺旋体复合体(以下简称莱姆病)的螺旋体引起,是北方半球最常见的蜱媒感染(1)。感染引起关节炎的可能性导致其在1975年被确认为临床实体(2),从那时起,美国和其他地方报告的病例数量稳步增加。疾病控制和预防中心(CDC)估计,美国莱姆病的年发病率约为30万,比医生报告的数字高出10倍。这篇综述旨在为风湿病学家提供目前对北美莱姆病的了解,重点是关节炎的发病机制和治疗的预期结果。
Lyme disease, caused by spirochetes of the Borrelia burgdorferi sensu lato complex (hereafter referred to as Lyme borrelia), is the most common tick-borne infection in the northern hemisphere (1). The potential for the infection to cause arthritis led to its recognition as a clinical entity in 1975 (2), and since then, the number of reported cases has steadily increased in the United States and elsewhere. The Centers for Disease Control and Prevention (CDC) estimates the annual case incidence of Lyme disease in the United States is~ 300,000, ten-fold more than the number reported by physicians. This review is intended to provide rheumatologists with a current understanding of North American Lyme disease, with emphasis on arthritis pathogenesis and expected outcomes from treatment.
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