Association of PEDF polymorphisms with age-related macular degeneration and polypoidal choroidal vasculopathy: a systematic review and meta-analysis.
Association of PEDF polymorphisms with age-related macular degeneration and polypoidal choroidal vasculopathy: a systematic review and meta-analysis.
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DOI：
10.1038/srep09497
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发表时间：
2015-03-30
影响因子：
4.6
通讯作者：
Chen LJ
中科院分区：
文献类型：
--
作者：
Ma L;Tang SM;Rong SS;Chen H;Young AL;Kumaramanickavel G;Pang CP;Chen LJ
这项研究评估了色素上皮衍生因子(PEDF)基因与老年性黄斑变性(AMD)和息肉状脉络膜血管病变(PCV)的关系。检索MEDLINE和EMBASE截至2014年8月21日的文献，检索PEDF与AMD和/或PCV的病例对照研究。报道的研究提供了足够的基因和/或等位基因信息。计算各多态性的合并优势比(OR)和95%可信区间(CI)。我们的文献检索得到297条记录。在排除重复和信息不完全的报告后，8项研究符合荟萃分析的条件，包括2284名AMD患者和317名PCV患者，371名对照。对4个PEDF基因进行Meta分析：rs1136287、rs12150053、rs12948385和rs9913583，但均未发现与AMD或PCV显著相关。研究最多的基因rs1136287与AMD的合并OR值为1.02(95%CI：0.94~1.11，P=0.64)。在按种族划分的亚组分析中，没有发现显著的相关性。单一报告中存在的多态现象没有相关性。因此，文献中现有的数据不支持PEDF在AMD和PCV遗传易感性中的作用，尽管在特定人群中复制是有必要的。由于PCV的混合样本量较小，因此需要在较大的PCV样本中进行PEDF基因分型。
This study assesses the association of the pigment epithelium-derived factor (PEDF) gene with age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). Publications in MEDLINE and EMBASE up to 21/08/2014 were searched for case-control association studies of PEDF with AMD and/or PCV. Reported studies giving adequate genotype and/or allele information were included. Pooled odds ratios (OR) and 95% confidence intervals (CI) of each polymorphism were estimated. Our literature search yielded 297 records. After excluding duplicates and reports with incomplete information, 8 studies were eligible for meta-analysis, involving 2284 AMD patients versus 3416 controls, and 317 PCV patients versus 371 controls. Four PEDF polymorphisms were meta-analyzed: rs1136287, rs12150053, rs12948385 and rs9913583, but none was significantly associated with AMD or PCV. The most-investigated polymorphism, rs1136287, had a pooled-OR of 1.02 (95% CI: 0.94–1.11, P = 0.64) for AMD. In subgroup analysis by ethnicity, no significant association was identified. Polymorphisms present in single report showed no association. Therefore, existing data in literature does not support the role of PEDF in the genetic susceptibility of AMD and PCV, although replication in specific populations is warranted. Since the pooled-sample size for PCV was small, there is a need of PEDF genotyping in larger samples of PCV.
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DOI：
10.1007/s12177-010-9055-1
发表时间：
2010-06-01
期刊：
Journal of ocular biology, diseases, and informatics
影响因子：
--
作者：
Imai, Daisuke;Mori, Keisuke;Yoneya, Shin
通讯作者：
Yoneya, Shin
影响因子：
4.2
作者：
Campochiaro, PA;Nguyen, QD;Wei, LL
通讯作者：
Wei, LL
影响因子：
3.5
作者：
Cipriani, Valentina;Leung, Hin-Tak;Yates, John R. W.
通讯作者：
Yates, John R. W.
影响因子：
3.7
作者：
Gomi, Fumi;Tano, Yasuo
通讯作者：
Tano, Yasuo
影响因子：
2
作者：
Harbord, Roger M.;Egger, Matthias;Sterne, Jonathan A. C.
通讯作者：
Sterne, Jonathan A. C.