ACUTE EFFECT OF HUMAN RECOMBINANT INSULIN-LIKE GROWTH-FACTOR-I ON RENAL-FUNCTION IN HUMANS
ACUTE EFFECT OF HUMAN RECOMBINANT INSULIN-LIKE GROWTH-FACTOR-I ON RENAL-FUNCTION IN HUMANS
复制标题
DOI：
10.1159/000188667
复制
发表时间：
1995-09-01
期刊：
影响因子：
2.5
通讯作者：
DEFRONZO, RA
中科院分区：
文献类型：
--
作者：
GIORDANO, M;DEFRONZO, RA
我们研究了胰岛素样生长因子I（IGF-I）对8名正常受试者肾功能的急性影响，这些受试者以0.4 μ g/kg的速率静脉输注IGF-I 3小时。在开始IGF-I输注后，血浆IGF-I浓度迅速上升，并在90分钟后达到平台，其是基础值的三倍。在IGF-I输注期间，肾小球滤过率进行性升高（从93 +/- 4至121 +/- 6 ml/173 m 2）。min; p < 0.01）和肾血浆流量（从529 +/- 31至703 +/- 55 ml/1.73 m（2）。min; p < 0.01），滤过分数无变化。在研究的最后90分钟内，钾和磷酸盐的血浆水平显著降低，而血浆钠浓度保持不变。在IGF-I输注期的最后90分钟内，观察到钠、钾和磷酸盐的排泄分数显著降低。心率适度升高，平均动脉压无变化。这些发现表明，当急性给药时，IGF-I是一种有效的肾脏抑制剂。血管扩张剂，但是是抗利尿剂。IGF-I还增强肾外组织对钾和磷酸盐的摄取，并减少肾钾和磷酸盐的排泄。
We examined the acute effects of insulin-like growth factor I (IGF-I) on renal function in 8 normal subjects who received a 3-hour intravenous infusion of IGF-I at a rate of 0.4 mu g/kg . min. After starting the IGF-I infusion, the plasma IGF-I concentration rose quickly and achieved a plateau after 90 min that was threefold above the basal value. During IGF-I infusion, progressive rises in glomerular filtration rate (from 93 +/- 4 to 121 +/- 6 ml/173 m(2) . min; p < 0.01) and renal plasma flow (from 529 +/- 31 to 703 +/- 55 ml/1.73 m(2) . min; p < 0.01) were observed, with no change in filtration fraction. The plasma levels of potassium and phosphate decreased significantly during the last 90 min of the study, while the plasma sodium concentration remained unchanged. A significant decrease in the fractional excretion of sodium, potassium, and phosphate was observed during the last 90 min of the IGF-I infusion period. The heart rate rose modestly with no change in mean arterial pressure. These findings show that, when administered acutely, IGF-I is a potent renal. vasodilator, but is antinatriuretic. IGF-I also enhances potassium and phosphate uptake by extrarenal tissues and reduces renal potassium and phosphate excretion.