CD28 and CD27 costimulation of CD8+ T cells: a story of survival.
CD28 and CD27 costimulation of CD8+ T cells: a story of survival.
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CD8 T 细胞的 CD28 和 CD27 共刺激：生存的故事。
DOI：
10.1007/978-0-387-34814-8_11
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发表时间：
2007
影响因子：
--
通讯作者：
Katsikis,PeterD
中科院分区：
文献类型：
--
作者：
Dolfi,DouglasV;Katsikis,PeterD
The role of costimulation in antiviral CD8+ T cells responses is becoming increasingly important as we try to develop adjuvant technologies for therapeutic or vaccine applications. Understanding how costimulation signals work and being able to harness their function to promote robust and protective immune responses is of particular interest. Much of current immunological research is addressing the many costimulatory molecules that are being discovered and characterized in order to elucidate the different mechanisms by which they work. It is becoming clear that multiple costimulation molecules are involved during the different phases of the CD8+ T cell response providing important proliferative and survival signals for these cells. The concept of T cell costimulation has evolved from the initial concept of the single CD28 second signal to an increasingly complex array of costimulation signals that involve multiple members of the B7:CD28 and TNFα/TNFR families. This review will focus on CD28 and CD27 costimulation and examine their involvement in the costimulation of CD8+ T cell responses and the role of such costimulation in the survival of activated, resting, and memory CD8+ T cells. We will also examine the importance of costimulatory-induced survival in antiviral CD8+ T cell responses.
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探索记忆 T 细胞生成途径。
DOI：
10.1172/jci14005
发表时间：
2001
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
F. Sallusto;Antonio Lanzavecchia
通讯作者：
Antonio Lanzavecchia
单细胞水平体内 T 细胞克隆扩增的动力学和要求：效应器功能与增殖能力相关。
DOI：
--
发表时间：
1999
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Gudmundsdottir,H;Wells,AD;Turka,LA
通讯作者：
Turka,LA
成熟和未成熟胸腺细胞中通过 CD4、CD8 和 CD28 进行信号转导。
DOI：
--
发表时间：
1991
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Turka,LA;Linsley,PS;Paine3rd,R;Schieven,GL;Thompson,GB;Ledbetter,JA
通讯作者：
Ledbetter,JA
影响因子：
32.4
作者：
Jung, S;Unutmaz, D;Lang, RA
通讯作者：
Lang, RA
影响因子：
4.4
作者：
Laurence A. Turka;J. Ledbetter;Kelvin P. Lee;C. June;C. Thompson
通讯作者：
Laurence A. Turka;J. Ledbetter;Kelvin P. Lee;C. June;C. Thompson