Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis.
Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis.
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DOI：
10.1016/j.tube.2016.05.003
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Warren RM
中科院分区：
文献类型：
--
作者：
Whitfield MG;Streicher EM;Dolby T;Simpson JA;Sampson SL;Van Helden PD;Van Rie A;Warren RM
吡嗪酰胺耐药性在耐药表型谱中基本未知。我们总结了南非临床分离株对PZA耐药的数据。当考虑将PZA纳入耐利福平结核病或耐多药结核病患者的治疗时，应进行PZA DST。
Pyrazinamide resistance is largely unknown in the spectrum of drug resistant phenotypes. We summarize data on PZA resistance in clinical isolates from South Africa. PZA DST should be performed when considering its inclusion in treatment of patients with rifampicin-resistant TB or MDR-TB.