Normal and abnormal maternal metabolism during pregnancy
Normal and abnormal maternal metabolism during pregnancy
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DOI：
10.1016/j.siny.2008.09.004
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发表时间：
2009-04-01
影响因子：
3
通讯作者：
McLaughlin, Ciara
中科院分区：
文献类型：
--
作者：
Hadden, David R.;McLaughlin, Ciara
妊娠期间的代谢适应对于满足妊娠的生理需求以及胎儿的充分生长发育是必不可少的。人们对怀孕期间的碳水化合物代谢有相当大的兴趣，糖尿病是葡萄糖代谢的主要障碍，也是一个相当重要的研究重点。虽然蛋白质和脂肪代谢障碍在怀孕期间被认识到，但它们的影响却没有得到太多关注。空腹血糖值在怀孕早期下降，血浆游离脂肪酸上升，酮体生成增强，血浆氨基酸下降。妊娠晚期肝脏对胰岛素的敏感性降低，对糖类、脂肪和氨基酸代谢的适当改变起着关键作用，而这些代谢是胎儿正常发育和存活所必需的。(C)2008爱思唯尔有限公司。保留所有权利。
Metabolic adaptations during pregnancy are essential to meet the physiological demands of pregnancy as well as adequate growth and development of the fetus. There has been considerable interest in carbohydrate metabolism during pregnancy, with diabetes, the main disorder of glucose metabolism, a considerable focus for research. Whereas disorders of protein and lipid metabolism are recognised during pregnancy, their influence has received less attention. Fasting glucose values fall in early pregnancy with a rise in plasma free fatty acids, enhanced ketogenesis and a fall in plasma amino acids. Decreased hepatic insulin sensitivity in later pregnancy plays a key role in bringing about the appropriate changes in carbohydrate, lipid and amino acid metabolism which are essential for normal fetal development and survival. (C) 2008 Elsevier Ltd. All rights reserved.