α‐Hemolysin, γ‐hemolysin, and leukocidin from Staphylococcus aureus: Distant in sequence but similar in structure
α‐Hemolysin, γ‐hemolysin, and leukocidin from Staphylococcus aureus: Distant in sequence but similar in structure
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金黄色葡萄球菌中的 α-溶血素、γ-溶血素和杀白细胞素：序列相距较远，但结构相似
DOI：
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Langzhou Song
中科院分区：
文献类型：
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作者：
E. Gouaux;M. Hobaugh;Langzhou Song
金黄色葡萄球菌的α-溶血素从一种水溶性的单体物种聚集到靶细胞表面的膜结合七聚体上，产生充满水的通道，导致细胞死亡和裂解。金黄色葡萄球菌还产生γ-溶血素和杀白素毒素，这两种毒素在红细胞和白细胞的破坏和溶解中起着两种成分的作用。在α-溶血素七聚体结构的背景下，对γ-溶血素、α-溶血素和杀白素的比对序列分析支持这样的结论：尽管α-溶血素与γ-溶血素和杀白素毒素之间的序列同源性处于所谓的黄光区，但原型的三维结构可能是保守的。类似于α-溶血素，γ-溶血素和杀白素也可能形成寡聚的跨膜通道，其中一个反平行的β桶构成主要的膜嵌入区。
α‐Hemolysin from Staphylococcus aureus assembles from a water‐soluble, monomeric species to a membrane‐bound heptamer on the surface of target cells, creating water‐filled channels that lead to cell death and lysis. Staphylococcus aureus also produces the γ‐hemolysin and leukocidin toxins, which function as two component toxins in the disruption and lysis of erythrocytes and leukocytes. Analysis of the aligned sequences of α‐hemolysin, γ‐hemolysin, and leukocidin in the context of the α‐hemolysin heptamer structure supports the conclusion that even though the level of sequence identity between α‐hemolysin and the γ‐hemolysin and leukocidin toxins is in the so‐called twilight zone, the three‐dimensional structures of the protomers are probably conserved. By analogy with α‐hemolysin, γ‐hemolysin and leukocidin may also form oligomeric, transmembrane channels in which an anti‐parallel β‐barrel constitutes the primary membrane‐embedded domain.
DOI：
10.1073/pnas.91.26.12828
发表时间：
1994-12-20
影响因子：
11.1
作者：
GOUAUX, JE;BRAHA, O;BAYLEY, H
通讯作者：
BAYLEY, H
DOI：
10.1073/pnas.87.1.118
发表时间：
1990
影响因子：
11.1
作者：
Randall F. Smith;Temple F. Smith
通讯作者：
Randall F. Smith;Temple F. Smith