Localized scleroderma histologically characterized by liquefaction degeneration and upper dermis fibrosis: a possible association with chemotherapy
Localized scleroderma histologically characterized by liquefaction degeneration and upper dermis fibrosis: a possible association with chemotherapy
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局部硬皮病组织学特征为液化变性和上层真皮纤维化：可能与化疗有关
DOI：
10.1111/ced.14216
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发表时间：
2020
影响因子：
4.1
通讯作者：
Y. Asano
中科院分区：
文献类型：
--
作者：
S. Toyama;S. Sato;Y. Asano
局限性硬皮病（LSc）或硬斑病是皮肤和皮下组织（如皮下脂肪、筋膜、肌肉和骨骼）的自身免疫性炎症性疾病，导致广泛纤维化和不可逆的畸形。由于线性硬皮病（LSc 的一个子集）代表沿着 Blaschko 线分布的皮肤病变，因此 LSc 被认为是由免疫药物消除最初源自单个体细胞突变的外胚层祖细胞的细胞造成的组织损伤引起的。
Localized scleroderma (LSc) or morphea is an autoimmune inflammatory disorder of the skin and underlying tissues, such as subcutaneous fat, fascia, muscles and bones, resulting in extensive fibrosis and irreversible deformity. Since linear scleroderma, a subset of LSc, represents skin lesions distributed along with Blaschko's lines, LSc is thought to be caused by tissue damage due to immune-medicated elimination of cells originally derived from a single somatically mutated ectodermal progenitor cell.