LINEAR RELATIONSHIP BETWEEN THE VOLUME OF HYPERTROPHIC CHONDROCYTES AND THE RATE OF LONGITUDINAL BONE-GROWTH IN GROWTH PLATES
LINEAR RELATIONSHIP BETWEEN THE VOLUME OF HYPERTROPHIC CHONDROCYTES AND THE RATE OF LONGITUDINAL BONE-GROWTH IN GROWTH PLATES
复制标题
DOI：
10.1002/jor.1100090306
复制
发表时间：
1991-05-01
影响因子：
2.8
通讯作者：
WILSMAN, NJ
中科院分区：
文献类型：
--
作者：
BREUR, GJ;VANENKEVORT, BA;WILSMAN, NJ
在这项研究中，我们测试的假设，肥大细胞的体积变化直接与纵向骨生长的速度。 肥大软骨细胞的体积（使用体视学技术）和纵向骨生长每24小时（使用土霉素标记技术），在近端和远端的桡骨生长板和近端和远端的胫骨生长板的21和35日龄戴帽大鼠和21和35日龄尤卡坦猪进行了测量。 我们证明了一个高的相关系数（大鼠0.98，猪0.83）之间的最终体积的肥大软骨细胞和纵向骨生长的速度在很宽的范围内的生长速度和体积的肥大软骨细胞。 此外，我们证明了纵向骨生长速率和肥大软骨细胞的最终体积之间的正线性关系。 大鼠与猪的回归线斜率不同。 这种关系与动物生长板的位置和动物的年龄无关。 这些数据表明，可能存在调节肥大软骨细胞体积变化的机制，并且软骨细胞体积增加是纵向骨生长速率的主要决定因素。 然而，细胞肥大对纵向骨生长的相对贡献在大鼠中可能不同于在猪中。
In this study, we tested the hypothesis that hypertrophic cell volume varies directly with the rate of longitudinal bone growth. The volume of hypertrophic chondrocytes (using stereological techniques) and longitudinal bone growth per 24 h (using oxytetracycline labeling techniques) were measured in the proximal and distal radial growth plates and the proximal and distal tibial growth plates of 21- and 35-day-old hooded rats and 21- and 35-day-old Yucatan pigs. We demonstrated a high coefficient of correlation (rats 0.98, pigs 0.83) between the final volume of hypertrophic chondrocytes and the rate of longitudinal bone growth over a wide range of growth rates and volumes of hypertrophic chondrocytes. In addition, we demonstrated a positive linear relationship between the rate of longitudinal bone growth and the final volume of hypertrophic chondrocytes. The slope of the regression line was different for rats than for pigs. The relationship was independent of the location of the growth plate in the animal and the age of the animal. The data suggest that mechanisms regulating volume changes in hypertrophic chondrocytes may exist and that chondrocytic volume increase is a major determinant of the rate of longitudinal bone growth. However, the relative contribution of cellular hypertrophy to longitudinal bone growth may be different in rats than in pigs.