EFFECTS OF AGING ON MICROGLIA IN THE NORMAL RAT-BRAIN - IMMUNOHISTOCHEMICAL OBSERVATIONS
EFFECTS OF AGING ON MICROGLIA IN THE NORMAL RAT-BRAIN - IMMUNOHISTOCHEMICAL OBSERVATIONS
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DOI：
10.1097/00001756-199406020-00016
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发表时间：
1994-06-02
期刊：
影响因子：
1.7
通讯作者：
YOSHIDA, M
中科院分区：
文献类型：
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作者：
OGURA, K;OGAWA, M;YOSHIDA, M
在年轻（8周）和老年（12个月）大鼠的大脑不同区域中，用小鼠单克隆抗体（OX-6和X-42）染色的分支小胶质细胞的数量进行了比较。OX-6阳性小胶质细胞的数量随着年龄的增长而增加，但OX-42阳性小胶质细胞没有。青年组和老年组大鼠脑白色质中OX-6阳性小胶质细胞的数量均高于灰质，而白色质中OX-42阳性小胶质细胞的数量与灰质相同。OX-42染色活化和静息状态的小胶质细胞，而OX-6主要染色活化状态的小胶质细胞。我们的研究结果表明，小胶质细胞成为激活与年龄相关的变化，特别是在白色的问题。
THE numbers of ramified microglia stained by mouse monoclonal antibodies (OX-6 and X-42) in various regions of the brain were compared in the young (8 weeks) and aged (12 months) rats. OX-6-positive microglia increased in number with ageing, but OX-42-positive microglia did not. In both young and aged rats, the number of OX-6-positive microglia in white matter was higher than that in grey matter, but the number of OX-42-positive microglia in white matter was the same as that in grey matter. OX-42 stains microglia in both activated and resting states, whereas OX-6 stains mainly microglia in the activated state. Our findings suggest that microglia become activated with age-related changes, especially in white matter.