Serotonin transporter genetic variation and biased attention for emotional word stimuli among psychiatric inpatients
Serotonin transporter genetic variation and biased attention for emotional word stimuli among psychiatric inpatients
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DOI：
10.1037/0021-843x.116.1.208
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发表时间：
2007-02-01
影响因子：
4.6
通讯作者：
Miller, Ivan W.
中科院分区：
文献类型：
--
作者：
Beevers, Christopher G.;Gibb, Brandon E.;Miller, Ivan W.
5-羟色胺转运基因（5-HTTLPR）启动子区域可变重复序列中的短等位基因与大脑中处理情绪刺激的关键区域的更强激活有关。作者研究了5-HTTLPR启动子多态性的变异是否也与情绪刺激的注意偏差的个体差异有关。以标准点探针反应时间任务的形式向精神科住院病人提供焦虑和烦躁情绪状态相关的词汇。与携带两个长等位基因的参与者相比，携带短5-HTTLPR等位基因的参与者对焦虑单词刺激表现出更强的注意偏向。对烦躁字刺激没有观察到遗传组间的差异。这项初步研究的发现强调了整合精神病理学的遗传和认知模型的潜力。
The short allele in a variable repeat sequence of the promoter region of the serotonin transporter gene (5-HTTLPR) has been associated with stronger activation in brain regions critical for processing emotional stimuli. The authors examined whether variants of the 5-HTTLPR promoter polymorphism were also associated with individual differences in attentional biases for emotional stimuli. Words related to anxious and dysphoric emotional states were presented to psychiatric inpatients in a standard dot-probe reaction time task. Compared with participants with two long alleles, carriers of the short 5-HTTLPR allele exhibited a stronger attentional bias for anxious word stimuli. No genetic group difference was observed for dysphoric word stimuli. Findings from this preliminary study highlight the potential for integrating genetic and cognitive models of psychopathology.