Parental mental health and risk of poor mental health and death by suicide in offspring: a population-wide data-linkage study.
Parental mental health and risk of poor mental health and death by suicide in offspring: a population-wide data-linkage study.
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DOI：
10.1017/s2045796022000063
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发表时间：
2022-04-19
影响因子：
8.1
通讯作者：
O'Reilly, D.
中科院分区：
文献类型：
--
作者：
Maguire, A.;Ross, E.;O'Reilly, D.
自杀是一个重大的公共卫生问题。确定风险最大的人群对于确保实施有效的干预措施至关重要。心理健康（MH）已知具有遗传成分，并且父母的MH与后代的MH相关。然而，关于父母精神病理对后代自杀风险的影响知之甚少。这项研究的目的是确定与父母的不良MH生活在一起的孩子是否有更高的不良MH或自杀死亡的风险。这项全人口队列研究将2011年北爱尔兰人口普查的数据与6年的死亡记录（2011 - 2016年）联系起来。关于MH状况的信息，以及其他个人和家庭层面的属性，来自2011年人口普查。在调整社会人口特征后，采用Logistic回归来检验父母不良MH和子女MH与自杀风险之间的关系。总体而言，在618970人的队列中，11.6%的人与报告MH较差的父母住在一起；1.6%的人报告自己的MH不佳，0.04% （n = 260）死于自杀。与患有不良MH的父母生活在一起会增加后代患不良MH的几率（OR = 2.80, 95% CI 2.59-3.03）。在调整了年龄、性别、身体疾病、社会经济地位和自己的MH后，与父母中有一方患有不良MH的儿童相比，父母中有一方患有不良MH的儿童死于自杀的可能性高出76% （OR = 1.76, 95% CI 1.31-2.36）。对于父母双方都有不良行为的儿童，效应量增加，24岁以下儿童的效应量更高。与精神健康状况不佳的父母一起生活是子女精神健康状况不佳和自杀的重要危险因素，即使在调整个人精神健康状况后也是如此。在治疗父母的精神疾病时，还应考虑对其子女的潜在干预措施。
Suicide is a major public health concern. Identifying those most at risk is vital to ensure the implementation of effective interventions. Mental health (MH) is known to have a genetic component and parental MH is associated with offspring MH. However, little is known about the effect of parental psychopathology on offspring suicide risk. The aim of this study is to determine if children living with parents with poor MH are at an increased risk of poor MH, or death by suicide. This population-wide cohort study linked data from the 2011 Northern Ireland Census to 6 years' death records (2011–2016). Information on MH status, in addition to other individual and household-level attributes, was derived from the 2011 Census. Logistic regression was utilised to examine the association between parental poor MH and offspring MH and suicide risk, with adjustment for socio-demographic characteristics. Overall, 11.6% of the cohort of 618 970 individuals were residing with parents who reported poor MH; 1.6% reported poor MH themselves, and 0.04% (n = 260) died by suicide. Living with a parent with poor MH increased the odds of offspring poor MH (OR = 2.80, 95% CI 2.59–3.03). After adjustment for age, gender, physical illness, socio-economic status and own MH, children living with 1 parent with poor MH were 76% more likely to die by suicide compared to children of parents who did not report poor MH (OR = 1.76, 95% CI 1.31–2.36). The effect size increased for children living with 2 parents with poor MH, and was higher in children aged under 24 years. Living with a parent with poor MH is a significant risk factor for offspring poor MH and suicide, even after adjustment for personal MH status. When treating mental ill-health in parents, potential interventions for their children should also be considered.
DOI：
10.1016/j.ssmph.2021.100749
发表时间：
2021-03
期刊：
SSM - population health
影响因子：
--
作者：
Onyeka IN;O'Reilly D;Maguire A
通讯作者：
Maguire A