THE PRODUCT OF THE DROSOPHILA GENE VASA IS VERY SIMILAR TO EUKARYOTIC INITIATION FACTOR-4A
THE PRODUCT OF THE DROSOPHILA GENE VASA IS VERY SIMILAR TO EUKARYOTIC INITIATION FACTOR-4A
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DOI：
10.1038/335611a0
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发表时间：
1988-10-13
期刊：
影响因子：
64.8
通讯作者：
ASHBURNER, M
中科院分区：
文献类型：
--
作者：
LASKO, PF;ASHBURNER, M
黑胃果蝇的血管生成物仅在雌性生殖系中需要。输精管突变的雌性纯合后代缺乏后结构和极细胞。vasa基因组和互补DNA克隆的分离和鉴定表明，该转录物仅在雌性生殖系和早期胚胎中丰富。预测的氨基酸序列与翻译起始因子eIF-4A和人核抗原p68的氨基酸序列非常相似。
Thevasagene product ofDrosophila melanogasteris required only in the female germ line. Progeny of females homozygous for vasa mutations lack posterior structures and pole cells. Isolation and characterization of vasa genomic and complementary DNA clones show that the transcript is abundant in the female germ line and early embryos only. The predicted amino acid sequence is very similar to those of the translation initiation factor eIF-4A and the human nuclear antigen p68.