The balance between lung regulatory T cells and Th17 cells is a risk indicator for the acute exacerbation of interstitial lung disease after surgery: a case-control study.
The balance between lung regulatory T cells and Th17 cells is a risk indicator for the acute exacerbation of interstitial lung disease after surgery: a case-control study.
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DOI：
10.1186/s12890-023-02362-2
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发表时间：
2023-02-22
影响因子：
3.1
通讯作者：
Suzuki, Kenji
中科院分区：
文献类型：
--
作者：
Fukui, Mariko;Harada, Norihiro;Takamochi, Kazuya;Hayashi, Takuo;Matsunaga, Takeshi;Hattori, Aritoshi;Kawagoe, Izumi;Suzuki, Kenji
间质性肺病（ILD）急性加重（AE）（AE-ILD）是一种危及生命的疾病，是日本因肺癌接受肺切除术患者30天死亡的主要原因。本研究旨在阐明AE-ILD发病前肺组织免疫环境的特点。这项回顾性配对病例对照研究比较了术后AE-ILD患者和非AE-ILD患者肺组织中辅助性T细胞的免疫表型。共入组了2009年至2018年期间在我院接受肺癌手术切除并经病理诊断为特发性间质性肺炎（IIP）的135例患者。使用倾向评分分析对13例AE-IIP患者和122例无AE（非AE）患者进行匹配，并对每组12例病例进行比较。我们通过非肿瘤区肺组织的免疫染色评估了AE患者中辅助性T细胞（Th）1、Th 2、Th 17、调节性T细胞（Treg）和CD 8细胞在CD 3 + T细胞中的百分比以及Th 1：Th 2、Th 17：Treg和CD 8：Treg比率。我们发现AE组和非AE组之间的肺Th 17：Treg比率存在显著差异（1.47和0.79，p = 0.041）。而肺Th 1（21.3%和29.0%）、Th 2（34.2%和42.7%）、Th 17（22.3%和21.6%）、Treg（19.6%和29.1%）和CD 8 + T细胞（47.2%和42.2%）占CD 3 + T细胞的百分比在AE组和非AE组之间无显著差异。肺组织中Th 17：Treg细胞的比例在AE组中高于非AE组。本研究已获得我院伦理委员会批准（2，016，095）。在线版本包含补充材料，可通过10.1186/s12890-023-02362-2获得。
Acute exacerbation (AE) of interstitial lung disease (ILD) (AE-ILD) is a life-threatening condition and the leading cause of 30-day mortality among patients who underwent pulmonary resection for lung cancer in Japan. This study was conducted to clarify the characteristics of the immune environment of lung tissues before the onset of AE-ILD. This retrospective matched case-control study compared the immune phenotypes of helper T cells in lung tissues from patients with and without AE-ILD after surgery. In total, 135 patients who underwent surgical resection for lung cancer and were pathologically diagnosed with idiopathic interstitial pneumonia (IIP) at our institute between 2009 and 2018 were enrolled. Thirteen patients with AE-IIP and 122 patients without AE (non-AE) were matched using a propensity score analysis, and 12 cases in each group were compared. We evaluated the percentages of T helper (Th)1, Th2, Th17, regulatory T (Treg), and CD8 cells in CD3+ T cells and the Th1:Th2, Th17:Treg, and CD8:Treg ratios in patients with AE by immunostaining of lung tissues in the non-tumor area. We found a significant difference in the lung Th17:Treg ratio between the AE and non-AE groups (1.47 and 0.79, p = 0.041). However, we detected no significant differences in the percentages of lung Th1 (21.3% and 29.0%), Th2 (34.2% and 42.7%), Th17 (22.3% and 21.6%), Treg (19.6% and 29.1%), and CD8+ T cells (47.2% and 42.2%) of CD3+ T cells between the AE and non-AE groups. The ratio of Th17:Treg cells in lung tissues was higher in participants in the AE group than in those in the non-AE group. This study was approved by the ethics committee of our institute (2,016,095). The online version contains supplementary material available at 10.1186/s12890-023-02362-2.
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发表时间：
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影响因子：
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作者：
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