Reversible on/off conformational switching of pentafluorobenzoyl amide triggered by acid vapor and sublimation
Reversible on/off conformational switching of pentafluorobenzoyl amide triggered by acid vapor and sublimation
复制标题
酸蒸气和升华触发五氟苯甲酰胺的可逆开/关构象转换
DOI：
10.1039/d2ce00972b
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发表时间：
2022
期刊：
影响因子：
3.1
通讯作者：
Okamoto Iwao
中科院分区：
文献类型：
--
作者：
Yamasaki Ryu;Harada Misuzu;Ito Ai;Fukuda Kazuo;Matsumoto Shota;Karasawa Satoru;Okamoto Iwao
大多数基于酰胺骨架的构象分子开关在溶液中的使用受到限制。我们开发了一种具有酰胺骨架的分子开关，它不需要溶剂就可以使用。用盐酸蒸气(不溶解)和升华处理固体3，通过将二甲氨基转化为二甲氨基，改变了酰胺的构象。通过升华和泵送去除HCl，逆转了这一转变。晶体分析证实，这种转变是在升华状态下的气态而不是溶液状态下进行的，是一种开/关过程。
Most conformational molecular switches based on an amide skeleton are limited in their use in solution. We developed a molecular switch with an amide skeleton, which is applicable without a solvent. Treatment of solid 3 with HCl vapor (without dissolution) and sublimation switched the amide conformation by converting a dimethylamino group to a dimethylammonium group. The transformation was reversed by sublimation with pumping to remove HCl. This switching, which proceeds in the gas state in sublimation and not the solution state, was confirmed to be an on/off process by crystal analysis.