Tumour epithelial vimentin expression and outcome of pancreatic ductal adenocarcinomas.
Tumour epithelial vimentin expression and outcome of pancreatic ductal adenocarcinomas.
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DOI：
10.1038/bjc.2011.93
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发表时间：
2011-04-12
影响因子：
8.8
通讯作者：
Goggins, M.
中科院分区：
文献类型：
--
作者：
Handra-Luca, A.;Hong, S-M;Walter, K.;Wolfgang, C.;Hruban, R.;Goggins, M.
肿瘤上皮波形蛋白表达是间充质分化的标志，可能是具有更强侵袭性行为的癌的有用标志。本研究的目的是确定波形蛋白在胰腺导管腺癌中的表达程度和预后意义。应用免疫组化技术在387例手术切除的胰腺导管腺癌组织微阵列上检测Vimentin的表达。使用Kaplan-Meier方法和Cox多变量生存模型，vimentin免疫标记肿瘤细胞的百分比与预后和临床病理因素相关。总的来说，45%的原发性胰腺腺癌含有表达vimentin的肿瘤细胞，27.5%的癌症中有10%的细胞表达vimentin。Vimentin表达与组织学分化不良相关。通过单因素和多因素生存分析，肿瘤vimentin表达（P<0.01, HR 1.52, 95%可信区间1.14-2.04）是术后生存时间较短的一个指标，独立于其他临床病理变量。在手术切除的胰腺腺癌中，表达vimentin的肿瘤上皮细胞的存在独立预测了较短的术后生存期。
Tumour epithelial vimentin expression is a marker of mesenchymal differentiation and may be a useful marker of carcinomas with more aggressive behaviour. The aim of this study was to determine the extent and prognostic significance of vimentin expression in pancreatic ductal adenocarcinomas. Vimentin expression was detected by immunohistochemistry on tissue microarrays of surgically resected pancreatic ductal adenocarcinomas from 387 patients. The percentage of vimentin-immunolabelled neoplastic cells was correlated with outcome and with clinico–pathological factors using the Kaplan–Meier method and Cox multivariate survival models. In all, 45% of primary pancreatic adenocarcinomas contained neoplastic cells that expressed vimentin, and in 27.5% of the cancers >10% of cells expressed vimentin. Vimentin expression was correlated with poor histological differentiation. By both uni- and multivariate survival analysis, neoplastic vimentin expression (P<0.01, HR 1.52, 95% confidence interval 1.14–2.04) was an indicator of a shorter postsurgical survival independent of other clinico–pathological variables. The presence of vimentin-expressing tumour epithelial cells in surgically resected pancreatic adenocarcinomas independently predicted a shorter postsurgical survival.
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