Dopamine Transporter (DAT1) and Dopamine Receptor D4 (DRD4) Genotypes Differentially Impact on Electrophysiological Correlates of Error Processing
Dopamine Transporter (DAT1) and Dopamine Receptor D4 (DRD4) Genotypes Differentially Impact on Electrophysiological Correlates of Error Processing
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DOI：
10.1371/journal.pone.0028396
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发表时间：
2011-12-05
期刊：
影响因子：
3.7
通讯作者：
Herrmann, Martin J.
中科院分区：
文献类型：
--
作者：
Biehl, Stefanie C.;Dresler, Thomas;Herrmann, Martin J.
最近的研究，以及错误处理的理论模型分配基本的重要性，大脑的多巴胺能系统。然而，关于常见多巴胺能基因的变异如何影响错误处理的电生理相关性-错误相关负性（ERN）和错误正性（Pe）的研究仍然相对较少。因此，在本研究中，我们调查了DAT 1基因和DRD 4基因的多态性是否分别导致这些错误处理相关性的个体间差异。160名参与者完成了一个版本的埃里克森侧卫任务，同时记录了26通道EEG。该任务略有修改，以增加错误率。在数据分析过程中，参与者被分为两组，分别根据他们的DAT 1和DRD 4基因型。分析了正确反应后和错误反应后ERN和Pe的幅值以及错误反应和正确反应之间的幅值差。我们发现DAT 1基因型对Pe差异幅度有不同的影响，但对ERN差异幅度没有影响，而DRD 4基因型则相反。这些发现与大脑中多巴胺能传递的理论模型的预测一致。此外，他们还将影响多巴胺系统的疾病的临床研究结果与已知为高危基因型的遗传变异联系起来。
Recent studies as well as theoretical models of error processing assign fundamental importance to the brain's dopaminergic system. Research about how the electrophysiological correlates of error processing-the error-related negativity (ERN) and the error positivity (Pe)-are influenced by variations of common dopaminergic genes, however, is still relatively scarce. In the present study, we therefore investigated whether polymorphisms in the DAT1 gene and in the DRD4 gene, respectively, lead to interindividual differences in these error processing correlates. One hundred sixty participants completed a version of the Eriksen Flanker Task while a 26-channel EEG was recorded. The task was slightly modified in order to increase error rates. During data analysis, participants were split into two groups depending on their DAT1 and their DRD4 genotypes, respectively. ERN and Pe amplitudes after correct responses and after errors as well as difference amplitudes between errors and correct responses were analyzed. We found a differential effect of DAT1 genotype on the Pe difference amplitude but not on the ERN difference amplitude, while the reverse was true for DRD4 genotype. These findings are in line with predictions from theoretical models of dopaminergic transmission in the brain. They furthermore tie results from clinical investigations of disorders impacting on the dopamine system to genetic variations known to be at-risk genotypes.