Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence
Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence
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DOI：
10.1128/iai.70.8.4721-4725.2002
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发表时间：
2002-08-01
影响因子：
3.1
通讯作者：
Barbé, J
中科院分区：
文献类型：
--
作者：
Campoy, S;Jara, M;Barbé, J
已克隆了编码高亲和力锌摄取系统的沙门氏菌鼠伤寒血清型znuABC基因及其调节基因zur。鼠伤寒沙门氏菌血清型zur和znuC敲除突变体已通过标记交换构建。znuC突变体经口或腹腔接种BALB/c小鼠后，其50%致死量增加，而zur突变体仅在腹腔攻击时毒力降低。
The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.