Protection of hippocampal neurons from ischemia-induced delayed neuronal death by hepatocyte growth factor: A novel neurotrophic factor
Protection of hippocampal neurons from ischemia-induced delayed neuronal death by hepatocyte growth factor: A novel neurotrophic factor
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DOI：
10.1097/00004647-199804000-00001
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发表时间：
1998-04-01
影响因子：
6.3
通讯作者：
Nakamura, T
中科院分区：
文献类型：
--
作者：
Miyazawa, T;Matsumoto, K;Nakamura, T
肝细胞生长因子（HGF）是c-met原癌基因产物的天然配体，表现出促有丝分裂、促运动和形态发生活性，用于肝、肾和肺的再生。最近，肝细胞生长因子被清楚地表明，以促进神经突起生长在体外。为了确定HGF是否对体内神经元死亡具有神经保护作用，我们研究了HGF对蒙古沙土鼠短暂前脑缺血5分钟后海马迟发性神经元死亡的影响。连续缺血后纹状体内给予人重组HGF（10或30 μ g）7天，可有效防止麻醉和清醒条件下海马神经元的延迟性死亡。即使在缺血后6小时开始HGF输注（即，以延迟的方式），HGF表现出神经保护作用。我们的结论是，肝细胞生长因子，一种新的神经营养因子，有深刻的神经保护作用，对缺血后迟发性神经元死亡的海马，这可能有影响的发展新的治疗策略，缺血性神经元损伤的人类。
Hepatocyte growth factor (HGF), a natural ligand for the c-met protooncogene product, exhibits mitogenic, motogenic, and morphogenic activities for regeneration of the liver, kidney, and lung. Recently, HGF was clearly shown to enhance neurite outgrowth in vitro. To determine whether HGF has a neuroprotective action against the death of neurons in vivo, we studied the effect of HGF on delayed neuronal death in the hippocampus after 5-minute transient forebrain ischemia in Mongolian gerbils. Continuous postischemic intrastriatal administration of human recombinant HGF (10 or 30 mu g) for 7 days potently prevented the delayed death of hippocampal neurons under both anesthetized and awake conditions. Even when HGF infusion started 6 hours after ischemia (i.e., in a delayed manner), HGF exhibited a neuroprotective action. We conclude that HGF, a novel neurotrophic factor, has a profound neuroprotective effect against postischemic delayed neuronal death in the hippocampus, which may have implications for the development of new therapeutic strategies for ischemic neuronal damage in humans.